Prevalence of Depression and Psychological Distress and Perturbations of Cortisol Dynamics in Attendants of Hospitalized Patients: An Observational Pilot Study.
Prevalence of Depression and Psychological Distress and Perturbations of Cortisol Dynamics in Attendants of Hospitalized Patients: An Observational Pilot Study.
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抑郁和心理困扰的患病率以及住院患者服务员的皮质醇动态的扰动：一项观察性试验研究。
DOI：
10.7759/cureus.12067
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发表时间：
2020-12-13
期刊：
影响因子：
--
通讯作者：
Walia R
中科院分区：
文献类型：
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作者：
Pal R;Sachdeva N;Bhansali A;Sharma A;Walia R
背景：住院病人的护理人员容易产生不必要的压力，导致抑郁、焦虑、忧郁和心理困扰。最近的研究迎合了重症监护病房病人的护理人员，没有人冒险研究他们的皮质醇动力学。在此，我们已经评估了心理困扰和抑郁的程度之间的表面上健康的服务员的非危重病patients. Methods：非危重病患者收治的普通内科病房被选中的目的性抽样和一个服务员从每个病人。排除了已知危险因素、精神疾病、慢性药物摄入、成瘾和超重/肥胖的患者。心理困扰和抑郁分别使用一般健康问卷12项（GHQ-12）和患者健康问卷（PHQ-9）进行评估。清晨血浆皮质醇，深夜血浆皮质醇（LNPC），深夜唾液皮质醇（LNSC），尿游离皮质醇（UFC），血浆皮质醇后过夜1 mg地塞米松administration. Results：排除后，39名参与者（男：女=2.3：1.6）。平均年龄为34.1±11.4岁。招募前在医院环境中的平均住院时间为16.2±1.2天。根据PHQ-9评分，55%的参与者患有抑郁症。根据GHQ-12评分，13%的参与者普遍存在心理困扰。抑郁症患者的中位LNPC/LNSC高于无抑郁症的患者，但无统计学显著差异。GHQ-12/PHQ-9分数和皮质醇dynamics. Conclusions之间没有显着的相关性：虽然抑郁症是普遍存在的约一半的病人服务员，皮质醇动力学在很短的时间内保持不变的两到三个星期。
Background: Attendants of in-hospital patients are prone to undue stress resulting in depression, anxiety, melancholy and psychological distress. Hitherto available studies cater to attendants of patients admitted in critical care units and none have ventured to look into their cortisol dynamics. Herein, we have evaluated the magnitude of psychological distress and depression amongst ostensibly healthy attendants of non-critically ill patients and correlated them with cortisol dynamics. Methods: Non-critically ill patients admitted to the general medicine ward were chosen by purposive sampling and one attendant was selected from each patient. Those with known risk factors, psychiatric illnesses, chronic drug intake, addictions, and overweight/obesity were excluded. Psychological distress and depression were assessed using the General Health Questionnaire 12-items (GHQ-12) and the Patient Health Questionnaire (PHQ-9), respectively. Morning plasma cortisol, late-night plasma cortisol (LNPC), late-night salivary cortisol (LNSC), urinary free cortisol (UFC), and plasma cortisol after overnight 1 mg dexamethasone administration were measured. Results: After exclusion, 39 participants were recruited (M:F=2.3:1.6). The mean age was 34.1±11.4 years. The mean duration of stay in hospital ambience prior to recruitment was 16.2±1.2 days. Based on the PHQ-9 score, 55% of the participants had depression. Psychological distress prevailed in 13% of participants as per the GHQ-12 score. The median LNPC/LNSC was higher in participants with depression compared to those with no depression, however, there was no statistically significant difference. There was no significant correlation between GHQ-12/PHQ-9 scores and cortisol dynamics. Conclusions: Although depression is prevalent in about half of the patient attendants, cortisol dynamics remain largely unaltered over a short period of two to three weeks.