Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.
复制标题
链球菌脂磷壁酸对 Meth A 纤维肉瘤的抗肿瘤作用。
作者：
H. Usami;A. Yamamoto;W. Yamashita;Y. Sugawara;S. Hamada;T. Yamamoto;K. Katō;S. Kokeguchi;H. Ohokuni;S. Kotani
研究了从化脓性链球菌中提取的脂磷壁酸（LTA）的抗肿瘤作用，并与其他链球菌细胞组分进行了比较。LTA抑制实体型和腹水型甲氨蝶呤纤维肉瘤的肿瘤生长，S。化脓性链球菌（OK-432）。没有其他细胞成分，例如细胞壁肽聚糖、组特异性C-碳水化合物或类型特异性M蛋白，抑制甲氧苯丙胺的生长。LTA，而不是其他细胞成分，诱导痤疮丙酸杆菌致敏小鼠的肿瘤坏死因子（TNF）。LTA对Meth A细胞无直接杀伤作用。这些结果表明，LTA可能是OK-432的一个重要的抗肿瘤成分，这种链球菌制剂的抗肿瘤机制之一是诱导TNF。
The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.
脂多糖介导的巨噬细胞激活：钙在产生抗肿瘤活性中的作用。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Drysdale,BE;Yapundich,RA;Shin,ML;Shin,HS
通讯作者：
Shin,HS