Transcriptional regulation by changes in tonicity
Transcriptional regulation by changes in tonicity
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DOI：
10.1046/j.1523-1755.2001.060002408.x
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发表时间：
2001-08-01
影响因子：
19.6
通讯作者：
Kwon, HM
中科院分区：
文献类型：
--
作者：
Handler, JS;Kwon, HM
大多数生物体对高渗环境的反应是积累小的有机溶质。与高浓度的电解质不同，小的有机溶质不会扰乱细胞内酶和其他大分子的活性。当肾髓质在抗利尿过程中变得高张时，多个信号通路被激活。这里。我们：综述紧张性反应增强剂(Tone)结合蛋白(TONEBP)的作用，TONEBP是一种在高张细胞中激活的转录因子。TONEBP的高张力激活是由于其移位到细胞核，以及TONEBP的mRNA和蛋白的增加。由于TONEBP在激活的淋巴细胞和发育中的组织中高度表达，因此它的作用可能不仅仅是对紧张性的反应。
Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contrast to high concentrations of electrolytes, the small organic solutes do not perturb the activity of enzymes and other macromolecules within the cell. When the renal medulla becomes hypertonic during antidiuresis, multiple signaling pathways are activated. Here. we: review the role of tonicity responsive enhancers (TonE) binding protein (TonEBP), a transcription factor activated in hypertonic cells. The activation of TonEBP by hypertonicity results from its translocation to the nucleus as well as an increase in TonEBP mRNA and protein. TonEBP may have a role beyond the response to tonicity since it is highly expressed in activated lymphocytes and in developing tissues.