Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women
Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women
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DOI：
10.1007/s00198-008-0573-7
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发表时间：
2008-09-01
影响因子：
4
通讯作者：
Dawson-Hughes, B.
中科院分区：
文献类型：
--
作者：
Bischoff-Ferrari, H. A.;Orav, E. J.;Dawson-Hughes, B.
在社区居住的老年男性和女性中，较高的生理睾酮水平可以防止福尔斯，在服用额外的维生素D和钙的人群中，这种益处可能会进一步增加。引言本研究的目的是调查老年男性和女性的性激素水平和跌倒风险。在性激素基线评估后，对住在家里的人进行了3年的随访。分析控制了几个协变量，包括基线25-羟基维生素D、性激素结合球蛋白和维生素D加钙治疗结果与最低四分位数相比，总睾酮最高四分位数的男性和女性下降的几率降低，（男性：OR = 0.22; 95% CI [0.07，0.72]/女性：OR = 0.34; 95% CI [0.14，0.83]）;如果这些个体也服用vitD+cal，则跌倒减少率增加（男性：OR = 0.16; 95%CI [0.03，0.90] /女性：OR = 0.15; 95%CI [0.04，0.57]）。同样，硫酸二氢表雄酮（DHEA-S）水平处于前四分位的女性跌倒风险较低（OR = 0.39; 95%CI [0.16，0.93]）。其他性激素和SHBG没有预测下降的男性或women.Conclusions较高的睾酮水平在两种性别和较高的DHEA-S水平的女性预测下降的风险降低60%以上。使用vitD+cal，较高生理睾酮水平的抗跌倒益处在男性中从78%提高到84%，在女性中从66%提高到85%。
Higher physiologic testosterone levels among community dwelling older men and women may protect against falls, and this benefit may be further increased among those taking additional vitamin D plus calcium.Introduction The aim of this study is to investigate sex hormone levels and fall risk in older men and women.Methods One hundred and ninety-nine men and 246 women age 65+ living at home were followed for 3 years after baseline assessment of sex hormones. Analyses controlled for several covariates, including baseline 25-hydroxyvitamin D, sex hormone binding globulin, and vitamin D plus calcium treatment (vitD+cal).Results Compared to the lowest quartile, men and women in the highest quartile of total testosterone had a decreased odds of falling (men: OR = 0.22; 95% CI [0.07,0.72]/women: OR = 0.34; 95% CI [0.14,0.83]); if those individuals also took vitD+cal, the fall reduction was enhanced (men: OR = 0.16; 95% CI [0.03,0.90] / women: OR = 0.15; 95% CI [0.04,0.57]). Similarly, women in the top quartile of dihydroepiandrosterone sulfate (DHEA-S) had a lower risk of falling (OR = 0.39; 95% CI [0.16,0.93]). Other sex hormones and SHBG did not predict falling in men or women.Conclusions Higher testosterone levels in both genders and higher DHEA-S levels in women predicted a more than 60% lower risk of falling. With vitD+cal, the anti-fall benefit of higher physiologic testosterone levels is enhanced from 78% to 84% among men and from 66% to 85% among women.