Oncological and Reproductive Outcomes in Patients With Advanced-Stage Ovarian Immature Teratoma: Experience From a Tertiary Center.
Oncological and Reproductive Outcomes in Patients With Advanced-Stage Ovarian Immature Teratoma: Experience From a Tertiary Center.
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晚期卵巢未成熟畸胎瘤患者的肿瘤学和生殖结果：三级中心的经验。
DOI：
10.3389/fonc.2022.822341
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
评价晚期卵巢未成熟畸胎瘤（IMT）患者的肿瘤学和生殖结局。我们回顾性分析了1985年1月至2020年12月期间接受手术治疗的晚期IMT患者的病历。生育保留手术（FSS）定义为保留子宫和至少一个附件。比较了接受FSS和根治性手术的患者的肿瘤结局。还联系了接受FSS的患者，以收集有关其月经史和生殖结果的信息。46例患者符合入选标准，其中38例接受了FSS，8例接受了根治性手术治疗。15例患者在中位随访时间74.2个月（范围：4.1-434.1个月）后复发。5年无病生存率（DFS）和总生存率（OS）分别为69.1%和89.9%。多变量分析确定次优肿瘤细胞减灭术是复发的唯一独立危险因素。不同手术方式的患者DFS或OS无显著差异。15例复发患者中有10例接受了最佳挽救手术，所有患者均存活，无明显疾病。在32例接受FSS的患者中，29例术后恢复月经，7例设计妊娠的患者中有5例共成功妊娠5次。卵巢IMT具有良好的预后，即使在晚期被诊断。FSS在希望保留生育能力的晚期IMT患者中是可行的。在初始和挽救手术期间，患者可能受益于最佳的细胞减灭术。
To evaluate the oncological and reproductive outcomes in patients with advanced-stage ovarian immature teratoma (IMT). We retrospectively reviewed the medical records of patients with advanced-stage IMT who were treated with surgery between January 1985 and December 2020. Fertility-sparing surgery (FSS) was defined as preservation of the uterus and at least one adnexa. Oncological outcomes were compared between patients who underwent FSS and radical surgery. Patients who underwent FSS were also contacted to gather information about their menstrual history and reproductive outcomes. Forty-six patients fulfilled the inclusion criteria, of whom 38 underwent FSS and eight were treated with radical surgery. Fifteen patients suffered recurrence after a median follow-up time of 74.2 months (range: 4.1–434.1 months). The 5-year disease-free survival (DFS) and overall survival (OS) rates were 69.1% and 89.9%, respectively. Multivariate analysis identified suboptimal cytoreductive surgery as the only independent risk factor for recurrence. There was no significant difference in DFS or OS between patients with different surgical procedures. Ten of the 15 relapsed patients had optimal salvage surgery and all remained alive with no evidence disease. Among the 32 patients who underwent FSS, 29 resumed menstruation after surgery, and five of seven patients who designed pregnancy achieved a total of five successful pregnancies. Ovarian IMT has a favorable prognosis, even when diagnosed at an advanced stage. FSS is feasible in patients with advanced-stage IMT who wish to preserve their fertility. Patients may benefit from optimal cytoreductive surgery during initial and salvage surgery.
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影响因子：
--
作者：
Uccello M;Boussios S;Samartzis EP;Moschetta M
通讯作者：
Moschetta M
影响因子：
3.7
作者：
Bentivegna, Enrica;Azais, Henri;Gouy, Sebastien
通讯作者：
Gouy, Sebastien
影响因子：
4.7
作者：
Park, Jeong-Yeol;Kim, Dae-Yeon;Nam, Joo-Hyun
通讯作者：
Nam, Joo-Hyun
影响因子：
4.7
作者：
MUNKARAH, A;GERSHENSON, DM;BURKE, TW
通讯作者：
BURKE, TW
影响因子：
3.3
作者：
Robboy, S J;Scully, R E
通讯作者：
Scully, R E