Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil
Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil
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DOI：
10.1007/s00705-009-0482-x
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发表时间：
2009-10-01
影响因子：
2.7
通讯作者：
Durigon, Edison Luiz
中科院分区：
文献类型：
--
作者：
Keller, Lilian Walsh;Barbosa, Maria Luisa;Durigon, Edison Luiz
人类细小病毒B19是唯一能引起人类疾病的红血球病毒属成员。最近对几株与B19有相当大序列差异的毒株的发现提出了一种新的细小病毒基因型分类，即1(B19)、2(A-6和LAI)和3(V9)。在它们的全部DNA序列中，这三种基因类型的差异类似于10%。在这里，我们报告了在巴西圣保罗进行的一项前瞻性研究中分离到的一株与基因3相关的菌株，命名为BR543。对BR543的几乎全长基因组序列的分析表明，该B19变异序列与Gh2768聚在一起，Gh2768来自加纳，属于3b亚型，并显示出大部分同义替换。
Human parvovirus B19 is the only member of the genus Erythrovirus that causes human disease. Recent findings of several strains with considerable sequence divergence from B19 have suggested a new classification for parvovirus genotypes as 1 (B19), 2 (A-6 and LaLi) and 3 (V9). In their overall DNA sequence, the three genotypes differ by similar to 10%. Here, we report the isolation of a genotype-3-related strain named BR543 during a prospective study conducted in Sao Paulo, Brazil. Analysis of the nearly full-length genome sequence of BR543 indicates that this B19 variant sequence clusters with Gh2768, a strain from Ghana belonging to subtype 3b, and showed mostly synonymous substitutions.