Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene
Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene
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DOI：
10.1038/s41429-020-0295-4
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发表时间：
2020-03-05
影响因子：
3.3
通讯作者：
Osada, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kato, Sho;Motoyama, Takayuki;Osada, Hiroyuki
我们发现蛋白质合成抑制剂hygromycin B诱导丝状真菌Fusarium sp. RK97-94产生次级代谢物，包括lucilactaene、NG-391、fusarubin、1233A和1233B。我们确定了HMG-CoA合成酶抑制剂1233A的生物合成基因簇。该生物合成基因簇由4个基因组成，其中一个基因与1233A的自抗性有关。
We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.