Model of Morphogenesis
Model of Morphogenesis
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DOI：
10.1089/cmb.2019.0414
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发表时间：
2020-02-07
影响因子：
1.7
通讯作者：
Morozova, Nadya
中科院分区：
文献类型：
--
作者：
Wang, Yue;Minarsky, Andrey;Morozova, Nadya
我们建立了形态发生的理论模型。这个模型使用每个细胞的表观遗传密码的概念来描述发育中的有机体中的细胞命运。也就是说，给定一个细胞及其邻近细胞的表观遗传光谱，我们可以确定它将执行的相应的细胞事件。这意味着一组细胞(包括胚胎或其部分)在任何时间点的性质也是已知的，因此，可以描述胚胎的进化。通过这种策略，可以在任何时候从受精卵开始建立组织、器官或胚胎的形状。作为该模型的重要组成部分，给出了细胞效力概念的形式化描述，并讨论了相关性质。
We build a theoretical model of morphogenesis. This model describes cell fate in the developing organism using the notion of epigenetic code of each cell. Namely, given the epigenetic spectra of a cell and its neighboring cells, we can determine the corresponding cell event it will perform. This means that the properties of a group of cells (comprising an embryo or its part) at any time point are also known, and thus, the evolution of an embryo can be described. By this strategy, it is possible to establish the tissue, organ, or embryo shapes at any time, starting from a zygote. As an essential part of the model, the formalization of the notion of cell potency is introduced, and the related properties are discussed.