The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging
The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging
复制标题
DOI：
10.1102/1470-7330.2013.0045
复制
发表时间：
2013-01-01
期刊：
影响因子：
4.9
通讯作者：
Stieltjes, Bram
中科院分区：
文献类型：
--
作者：
Ganten, Maria-Katharina;Schuessler, Maximilian;Stieltjes, Bram
目的：本研究的目的是描述和了解直肠癌在放化疗（CRT）下治疗引起的弥散参数变化。目前的文献在这方面显示了相互矛盾的结果。我们应用了体素内非相干运动模型，该模型允许区分扩散（D）和灌注（f）效应，以进一步阐明这些不同报告的潜在根本原因。材料与方法：18例接受术前CRT的原发性直肠癌患者在新辅助CRT之前、期间和之后使用弥散加权成像进行检查。使用体素内非相干运动方法，提取f和D，并与术后肿瘤降级和体积进行比较。结果：初始扩散衍生参数在较窄范围内（D-1 = 0.94 +/- 0.12 x 10（-3）mm（2）/s）。随访时，D显著升高（D-2=1.18 +/- 0.13 x 10（-3）mm（2）/s; P
Purpose: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports. Materials and methods: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume. Results: Initial diffusion-derived parameters were within a narrow range (D-1 = 0.94 +/- 0.12 x 10(-3) mm(2)/s). At follow-up, D rose significantly (D-2=1.18 +/- 0.13 x 10(-3) mm(2)/s; P