Air travel and fatal pulmonary embolism
Air travel and fatal pulmonary embolism
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DOI：
10.1160/th05-12-0813
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发表时间：
2006-05-01
影响因子：
6.7
通讯作者：
Skegg, DCG
中科院分区：
文献类型：
--
作者：
Parkin, L;Bell, ML;Skegg, DCG
尽管长途航空旅行通常被认为是静脉血栓栓塞的危险因素，但临床重要事件的风险尚未明确定义。我们在一项基于全国人口的描述性研究中估计了长途航空旅行后死于肺栓塞的绝对风险，该研究对 121 名年龄在 15-59 岁之间的男性和女性（大多数国际抵达者的年龄范围）进行了评估，其根本死因被认定为《国际疾病分类》（第九次修订版）代码 415.1、451 或 453。 11 名病例在致命事件发生前 4 周内曾进行过长途航空旅行。对于海外游客和新西兰居民来说，飞行时间至少三小时后，致命性肺栓塞的估计风险分别为每百万抵达者 0.5 例（95% CI 0.2-1.2）和 0.6 例（95% CI 0.2-1.4）。对于持续时间超过 8 小时的航空旅行，新西兰居民的风险为每百万抵达者 1.3 (95% CI 0.4-3.0)。我们还针对通常居住在新西兰并在选民名册上登记的病例（n = 99）进行了病例对照研究。对于每个案例，从选民名册中随机选择四名性别、年龄和选民相匹配的对照。在关键分析中（基于 88 例病例和 334 例对照），与未进行长途飞行的旅行者相比，飞行超过 8 小时的旅行者的调整后优势比为 7.9 (95% CI 1.1-55.1)。长途航空旅行者死于肺栓塞的风险高于非旅行者，但 15-59 岁人群的绝对风险似乎很小。
Although long-distance air travel is commonly regarded as a risk factor for venous thromboembolism, the risk of clinically important events has not been well defined. We estimated the absolute risk of dying from pulmonary embolism following long-distance air travel in a national population-based descriptive study of 121 men and women who were aged 15-59 years (the age range in which the majority of international arrivals are found) and whose underlying cause of death was certified as codes 415.1, 451, or 453 of the International Classification of Diseases (ninth revision). Eleven cases had undertaken long-distance air travel in the four weeks before the onset of the fatal episode. The estimated risks of fatal pulmonary embolism following a flight of at least three hours' duration were 0.5 (95% CI 0.2-1.2) and 0.6 (95% CI 0.2-1.4) per million arrivals for over-seas visitors and New Zealand residents, respectively. For air travel of more than eight hours' duration, the risk in New Zealand residents was 1.3 (95% CI 0.4-3.0) per million arrivals. We also conducted a case-control study based on those cases who were normally resident in New Zealand and registered on the electoral roll (n = 99). For each case, four controls matched for sex, age, and electorate, were randomly selected from the electoral roll. In the key analysis (based on 88 cases and 334 controls), the adjusted odds ratio for travellers who had flown for more than eight hours was 7.9 (95% CI 1.1-55.1) compared with those who did not undertake a long-distance flight. Long-distance air travellers have a higher risk of dying from pulmonary embolism than non-travellers, but the absolute risk in people aged 15-59 years appears to be very small.