Factors predicting survival in patients with advanced oesophageal cancer:: a prospective multicentre evaluation
Factors predicting survival in patients with advanced oesophageal cancer:: a prospective multicentre evaluation
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DOI：
10.1111/j.1365-2036.2007.03589.x
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发表时间：
2008-03-01
影响因子：
7.6
通讯作者：
Ruth, M.
中科院分区：
文献类型：
--
作者：
Bergquist, H.;Johnsson, A.;Ruth, M.
背景食管癌诊断时已是晚期，预后差，发病率高。在大多数情况下，姑息治疗是唯一的选择available.AimTo找到的因素，可以预测患者的生存率与不可治愈的癌症的食管或胃食管交界处，从而帮助选择治疗。进行健康相关生活质量问卷调查（EORTC QLQ C-30和QLQ OES 18），并对原发性肿瘤进行计算机断层扫描大小评估。单变量和多变量Cox回归分析，以确定潜在的预测survival.ResultsKarnofsky指数，发生转移（M-阶段），国际联盟反肿瘤阶段，计算机断层扫描衍生的肿瘤大小评估和10个25个规模和单项健康相关的生活质量问卷被发现与生存。在多因素分析中，健康相关生活质量问卷中的三个量表（身体功能，疲劳和反流）被发现增加了M期的预后信息，M期是最强的预测因子。（HR 1.9，P < 0.01）。健康的结果-相关的生活质量问卷调查可以提高对晚期食管癌或胃癌患者生存率的预测，食管交界处，从而有助于姑息治疗策略的选择。
BackgroundOesophageal cancer is often diagnosed at an advanced stage, with poor prognosis and severe morbidity. In majority of cases, palliative treatment is the only option available.AimTo find factors that can predict survival for patients with incurable cancer of the oesophagus or gastro-oesophageal junction and hence aid in the choice of treatment.MethodsNinety-six patients were included. Health-related quality of life questionnaires (EORTC QLQ C-30 and QLQ OES18) were administered and computerized tomography-derived size assessment of the primary tumours was performed. Univariate and multivariate Cox-regression analyses were used to determine potential predictors of survival.ResultsKarnofsky Index, occurrence of metastases (M-stage), Union International Contre le Cancer-stage, computerized tomography-derived tumour size assessment and 10 of 25 scales and single items from the health-related quality of life questionnaires were found to be related to survival. In the multivariate analysis, three of the health-related quality of life questionnaire scales (physical functioning, fatigue and reflux) were found to add prognostic information to M-stage, the single strongest predictor (HR 1.9, P < 0.01).ConclusionIn addition to M-stage, the outcome of health-related quality of life questionnaires can sharpen the prediction of survival in patients with advanced cancer of the oesophagus or gastro-oesophageal junction and thus aid in the choice of palliative treatment strategy.