Targeted nanosystem combined with chemo-photothermal therapy for hepatocellular carcinoma treatment
Targeted nanosystem combined with chemo-photothermal therapy for hepatocellular carcinoma treatment
复制标题
靶向纳米系统联合化疗光热疗法治疗肝细胞癌
DOI：
10.1016/j.colsurfa.2020.124711
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Yin Jian
中科院分区：
文献类型：
--
作者：
Wang Yan;Hu Jing;Xiang Danhua;Peng Xinyi;You Qingjun;Mao Yong;Hua Dong;Yin Jian
多模式疗法在临床肿瘤治疗中显示出显著的疗效。纳米技术为多功能给药系统提供了强有力的平台。本文采用聚乙二醇衍生物和乳糖酸对氧化石墨烯纳米片进行改性，以提高其生物相容性。选择具有多种生物学效应的抗癌药物姜黄素（CUR），通过π-π堆积法成功负载到纳米复合材料上，体外实验结果表明GO-PEG/LA-CUR复合材料具有良好的生物安全性和特异性靶向高表达去唾液酸糖蛋白受体（ASGPR）的肝癌细胞的能力。体内实验也表明GO-PEG/LA-CUR纳米复合物具有良好的生物分布。GO-PEG/LA-CUR经近红外（NIR）照射后对皮下肝癌荷瘤小鼠的肿瘤生长有明显抑制作用，抑瘤率达86%，证明了协同化学光热疗法（PTT）的疗效。治疗性纳米复合物可以成为临床HCC治疗的有用的PTT组合平台。
The multimodal therapies have showed significantly efficacy in clinical tumor treatment. Nanotechnology provides the powerful platform as multifunctional drug delivery system. Herein, graphene oxide (GO) nanosheets were prepared and modified with polyethylene glycol derivatives and lactobionic acid (LA), which improved their biocompatibility. The anticancer drug curcumin (CUR) that possess various biological effects was selected and successfully loaded onto the nanocomposites by π-π stacking.In vitroresults showed that the formulation of GO-PEG/LA-CUR has good biosafety and the ability to specifically target hepatocellular carcinoma cells that overexpress asialoglycoprotein receptor (ASGPR). Thein vivoexperiments also demonstrated excellent biodistribution of GO-PEG/LA-CUR nanocomposites. The tumor growth was significantly inhibited in subcutaneous HCC tumor-bearing mice treated with GO-PEG/LA-CUR after near-infrared (NIR) irradiation, with a tumor inhibition rate of 86 %, demonstrating the synergistic chemo-photothermal therapy (PTT) efficacy. The therapeutic nanocomposites can be a useful PTT-combined platform for the clinical HCC treatment.
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