Focal Cooling for Drug-Resistant Epilepsy: A Review.
Focal Cooling for Drug-Resistant Epilepsy: A Review.
复制标题
局部冷却治疗耐药性癫痫：综述。
DOI：
10.1001/jamaneurol.2022.1936
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发表时间：
2022-09-01
期刊：
影响因子：
29
通讯作者：
Goldenholz, Daniel M.
中科院分区：
文献类型：
--
作者：
Niesvizky-Kogan, Itamar;Bass, Michelle;Goldenholz, Shira R.;Goldenholz, Daniel M.
Epilepsy affects at least 1.2% of the population, with a third of cases considered drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may be a potential avenue for treatment, offering hope to people with DRE for seizure-freedom. The therapy leverages neuroscience and engineering principles to deliver a reversible treatment unhindered by pharmacology. Analogous to (but safer than) the use of global cooling in post-cardiac arrest and neonatal ischemic injury, extensive research supports the premise that focal cooling as a long-term treatment for epilepsy could be effective. The potential advantages of focal cooling are trifold: stopping epileptiform discharges, seizures, and status epilepticus safely across species (including humans). This review presents the most current evidence supporting focal cooling in epilepsy. Cooling has been demonstrated as a potentially safe and effective treatment modality for DRE, although it is not yet ready for use in humans outside of controlled clinical trials. The review will also offer a brief overview of the technical challenges related to focal cooling in humans, including the optimal device design and cooling parameters.
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影响因子：
4.1
作者：
Bakken, HE;Kawasaki, H;Howard, MA
通讯作者：
Howard, MA
DOI：
10.1109/tmrb.2020.3020687
发表时间：
2020-11-01
期刊：
IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS
影响因子：
--
作者：
Abe, Takuto;Fujiwara, Koichi;Kano, Manabu
通讯作者：
Kano, Manabu
影响因子：
16.2
作者：
Banerjee A;Egger R;Long MA
通讯作者：
Long MA
影响因子：
158.5
作者：
Bernard, SA;Gray, TW;Smith, K
通讯作者：
Smith, K
影响因子：
11.2
作者：
D'Ambrosio, Raimondo;Eastman, Clifford L.;Darvas, Felix;Fender, Jason S.;Verley, Derek R.;Farin, Federico M.;Wilkerson, Hui-Wen;Temkin, Nancy R.;Miller, John W.;Ojemann, Jeffrey;Rothman, Steven M.;Smyth, Matthew D.
通讯作者：
Smyth, Matthew D.