Circum-menarcheal bone acquisition is stress-driven: A longitudinal study in adolescent female gymnasts and non-gymnasts.
Circum-menarcheal bone acquisition is stress-driven: A longitudinal study in adolescent female gymnasts and non-gymnasts.
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月经初周周围骨获取是压力驱动的：一项针对青少年女性体操运动员和非体操运动员的纵向研究。
DOI：
10.1016/j.jbiomech.2018.07.017
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发表时间：
2018
影响因子：
2.4
通讯作者：
Dowthwaite,JodiN
中科院分区：
文献类型：
--
作者：
Troy,KarenL;Scerpella,TamaraA;Dowthwaite,JodiN
通过青少年锻炼进行的机械负荷是高度可修改的，代表了一种最大化成人骨量峰值的策略，有可能在人群中广泛实施以降低骨折风险。对于女孩来说，月经初潮周围的生长至关重要，大约 50% 的成人骨骼在 4 年内获得。在这里，我们前瞻性地跟踪了 10 名体操运动员和 12 名年龄匹配的非体操运动员，为期大约 4 年的初潮前后。 pQCT 和特定受试者有限元模型的组合用于测量各组之间骨获取和结构的差异，并确定特定机械因素预测骨结构变化的程度。在基线时，体操运动员的骨骼更坚固，包括 BMC 高出 26%、抗压强度高出 51%、小梁密度高出 21%。在研究期间，两组人的骨强度都增加了一倍以上。月经初潮前的主应力可以预测非体操运动员的 pQCT 变量的变化，但不能预测体操运动员的变化。非体操运动员的骨骼比体操运动员的骨骼变得更加不对称。我们的研究结果表明，在青春期接触体操负荷的多样化、强烈的机械信号对骨骼几何形状和机械功能有很大的好处。具体来说，与非体操运动员相比，体操运动员的骨骼能够更好地抵抗来自多个方向的负载，并且操作时的安全系数更高。
Mechanical loading through youth exercise is highly modifiable and represents a strategy to maximize peak adult bone mass, with the potential for broad implementation across the population to lower fracture risk. For girls, circum-menarcheal growth is critical, with around 50% of adult bone acquired over a 4-year period. Here, we prospectively followed 10 gymnasts and 12 age-matched non-gymnasts across approximately 4 years circum-menarche. A combination of pQCT and subject-specific finite element models were used to measure differences in bone acquisition and structure between the groups, and to determine the degree to which specific mechanical factors predict change in bone structure. At baseline, gymnasts had stronger bone, including 26% higher BMC, 51% greater compressive strength, and 21% higher trabecular density. Over the study period, both groups more than doubled their bone strength. Pre-menarcheal principal stresses predicted change in pQCT variables for non-gymnasts, but not gymnasts. The bone of non-gymnasts became more asymmetrical than the bone of gymnasts. Our results suggest that exposure to the diverse, intense mechanical signals of gymnastic loading during adolescence imparts substantial benefits to bone geometry and mechanical function. Specifically, the bone of gymnasts is better able to resist loading from multiple directions, and operates with a higher factor of safety compared to non-gymnasts.