Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers
Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers
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DOI：
10.1309/jh4q-25q5-0trv-w99u
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发表时间：
2000-02-01
影响因子：
3.5
通讯作者：
Monden, M
中科院分区：
文献类型：
--
作者：
Kawanishi, K;Doki, Y;Monden, M
细胞间粘附的丧失和细胞运动性的增加协同促进肿瘤细胞的侵袭。应用免疫组织化学方法检测90例胃癌组织中E-钙粘蛋白（ECD）和自分泌运动因子受体（AMFR）的表达。正常胃粘膜（对照）对ECD反应强，对AMFR反应弱。在研究病例中，47例ECD弱，39例AMFR强。弱ECD和强AMFR表达与肿瘤去分化相关。AMFR表达与浸润深度呈正相关，与淋巴结转移无关。ECD表达与淋巴结转移呈负相关，但与浸润深度无关。ECD与AMFR表达呈负相关。具有弱ECD和强AMFR表达的肿瘤显示出比具有强ECD和弱AMFR表达的肿瘤更具侵袭性的表型。ECD弱表达、AMFR强表达的肿瘤患者术后生存期明显短于其他组。由于它们参与了具有更侵袭性表型的肿瘤的发展途径，因此应检查ECD和AMFR以评估胃癌的生物学潜力。
Loss of intercellular adhesion and increased cell motility synergistically facilitate tumor cell invasion. We studied these factors in 90 patients with gastric cancers by using an immunohistochemical technique to detect strong or weak expression of E-cadherin (ECD) and autocrine motility factor receptor (AMFR). Normal gastric mucosa (control) reacted strongly for ECD and weakly for AMFR. In study cases, ECD was weak in 47 cases, and AMFR was strong in 39 cases. Weak ECD and strong AMFR expression were associated with tumor dedifferentiation. AMFR expression correlated positively with depth of invasion but not with lymph node metastasis. ECD expression correlated negatively with lymph node metastasis but not with depth of invasion. A strong inverse correlation was found between ECD and AMFR expression. Tumors with weak ECD and strong AMFR expression displayed a more aggressive phenotype than tumors with strong ECD and weak AMFR expression. The postoperative survival of patients with tumors with weak ECD and strong AMFR expression was significantly shorter than that of other groups. Since they are involved in the pathway to development of tumors with a more aggressive phenotype, ECD and AMFR should be examined to evaluate the biologic potential of gastric cancers.