Analysis of Synergistic Effects of Antimicrobial Peptide Arenicin-1 and Conventional Antibiotics

Analysis of Synergistic Effects of Antimicrobial Peptide Arenicin-1 and Conventional Antibiotics
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DOI:
10.1007/s10517-017-3708-z
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发表时间:
2017-04-01
影响因子:
0.7
通讯作者:
Ovchinnikova, T. V.
Ovchinnikova, T. V.
中科院分区:
医学4区
文献类型:
--
作者:
Bolosov, I. A.;Kalashnikov, A. A.;Ovchinnikova, T. V.

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研究了沙蚕抗菌肽arenicin-1与常用抗生素的联合作用。揭示了许多具有显著协同作用的药物组合。确定了抗菌活性评价条件的影响,并开发了排除假阳性试验结果的方法。
We studied combined effects of antimicrobial peptide arenicin-1 from lugworm Arenicola marina and some conventional antibiotics. A number of drug combinations with pronounced synergistic effects were revealed. The influence of antibacterial activity assessment conditions was determined and the methodology excluding false-positive test results was developed.