Race is associated with differences in airway inflammation in patients with asthma
Race is associated with differences in airway inflammation in patients with asthma
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DOI：
10.1016/j.jaci.2016.10.024
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发表时间：
2017-07-01
影响因子：
14.2
通讯作者：
Ackerman, Steven J.
中科院分区：
文献类型：
--
作者：
Nyenhuis, Sharmilee M.;Krishnan, Jerry A.;Ackerman, Steven J.
背景：与白色受试者相比，非裔美国受试者的哮喘负担更大。非裔美国人和白色受试者的气道炎症模式是否不同尚不清楚。目的：我们试图比较非裔美国人和白色受试者接受或不接受吸入性皮质类固醇治疗的痰气道炎症表型（ICS;分别为ICS+和ICS-）。我们做了二次自我分析-确定了参加由国家心肺血液研究所赞助的哮喘临床研究网络和哮喘网进行的临床试验的非裔美国人和白色哮喘受试者。进行人口统计学、临床特征和诱导痰后的痰细胞学检查。我们使用痰嗜酸性粒细胞2%的分界点来定义嗜酸性粒细胞（>= 2%）或非嗜酸性粒细胞（
Background: African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear.Objective: We sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively).Methods: We performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet. Demographics, clinical characteristics, and sputum cytology after sputum induction were examined. We used a sputum eosinophil 2% cut point to define subjects with either an eosinophilic (>= 2%) or noneosinophilic (