Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study.
Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study.
复制标题
DOI：
10.1136/ard.2011.150078
复制
发表时间：
2011-09
影响因子：
27.4
通讯作者：
Felson DT
中科院分区：
文献类型：
--
作者：
Haugen IK;Englund M;Aliabadi P;Niu J;Clancy M;Kvien TK;Felson DT
描述普通人群中放射学、糜烂性和症状性手部骨关节炎 (HOA) 的患病率和纵向病程。 Framingham 骨关节炎 (OA) 研究参与者在基线和 9 年随访时获得了双侧手部 X 光片。作者将关节水平的放射学 HOA 定义为 Kellgren-Lawrence 分级 (KLG)≥2，糜烂性 HOA 定义为 KLG≥2 加上糜烂，症状性 HOA 定义为 KLG≥2 加上疼痛/酸痛/僵硬。个体层面存在 HOA 定义为≥1 个受影响关节。患病率按年龄标准化（美国 2000 年人口 40-84 岁）。平均 (SD) 基线年龄为 58.9 (9.9) 岁（56.5% 为女性）。女性中 HOA 的年龄标准化患病率 (44.2%) 仅略高于男性 (37.7%)，而女性中糜烂性和症状性 OA 的年龄标准化患病率要高得多（9.9% vs 3.3%、15.9% vs 8.2%）。 9 年随访期间，女性 (34.6%) 和男性 (33.7%) 的 HOA 粗发生率相似，而基线时患有 HOA 的大多数女性 (96.4%) 和男性 (91.4%) 在随访期间出现进展。掌指骨和腕部骨关节炎的发生率较低，但男性比女性发生频率更高且发病年龄更早。糜烂性疾病的发生主要发生在基线时具有非糜烂性 HOA 的患者（相对于没有 HOA 的患者），并且女性 (17.3%) 比男性 (9.6%) 更常见。流行性 HOA 和偶发性 HOA 中通常以女性为主，但放射学 HOA 的情况不如症状性 HOA 和糜烂性 HOA 明确。随着人口老龄化，HOA的影响将进一步加大。
To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren–Lawrence grade (KLG)≥2, erosive HOA as KLG≥2 plus erosion and symptomatic HOA as KLG≥2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as ≥1 affected joint. The prevalence was age-standardised (US 2000 Population 40–84 years). Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase.
登录
查看更多内容
影响因子：
27.4
作者：
Bijsterbosch, J.;Watt, I.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
27.4
作者：
Botha-Scheepers, S.;Riyazi, N.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
27.4
作者：
Bijsterbosch, Jessica;Visser, Willemien;Kloppenburg, Margreet
通讯作者：
Kloppenburg, Margreet
DOI：
10.2106/00004623-200407000-00013
发表时间：
2004-07-01
影响因子：
5.3
作者：
Haara, MM;Heliovaara, M;Aromaa, A
通讯作者：
Aromaa, A
影响因子：
1.7
作者：
BUSBY, J;TOBIN, J;PLATO, CC
通讯作者：
PLATO, CC