Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease
Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease
复制标题
用于治疗炎症性肠病的位点特异性靶向药物递送系统
DOI：
10.1016/j.biopha.2020.110486
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发表时间：
2020-09-01
影响因子：
7.5
通讯作者：
Rao, Yuefeng
中科院分区：
文献类型：
--
作者：
Li, Xin;Lu, Chao;Rao, Yuefeng
炎症性肠病 (IBD) 包括克罗恩病和溃疡性结肠炎，表现为复杂且失调的免疫反应。迄今为止，IBD 尚无治愈方法；因此，常常需要终生服用维持药物。由于传统的 IBD 治疗策略不针对炎症部位，因此使用它们时仅观察到有限的疗效。此外，当使用常规药物治疗时，全身药物再分布导致严重副作用的可能性很高。因此，需要一种简单的疾病靶向药物递送系统。基于与IBD相关的病理生理变化，将药物直接递送至炎症部位的新型定点靶向药物递送策略可以增强药物积累并减少副作用。本综述总结了 IBD 治疗中的新型炎症靶向递送系统。它还讨论了该领域的挑战和新观点。
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis and manifests as a complex and dysregulated immune response. To date, there is no cure for IBD; thus, lifelong administration of maintenance drugs is often necessary. Since conventional IBD treatment strategies do not target the sites of inflammation, only limited efficacy is observed with their use. Moreover, the possibility of severe side effects resulting from systemic drug redistribution is high when conventional drug treatments are used. Therefore, a straightforward disease targeted drug delivery system is desirable. Based on the pathophysiological changes associated with IBD, novel site-specific targeted drug delivery strategies that deliver drugs directly to the inflammation sites can enhance drug accumulation and decrease side effects. This review summarizes novel inflammation targeted delivery systems in the management of IBD. It also discusses the challenges and new perspectives in this field.