The TET2 interactors and their links to hematological malignancies.
The TET2 interactors and their links to hematological malignancies.
复制标题
TET2相互作用者及其与血液学恶性肿瘤的联系。
作者：
Pan F;Weeks O;Yang FC;Xu M
10 - 11易位家族蛋白是DNA中将5-甲基胞嘧啶氧化为5-羟甲基胞嘧啶、5-甲酰胞嘧啶和5-羧基胞嘧啶的双加氧酶，是活性DNA去甲基化的早期步骤。TET2是TET蛋白家族的第二成员，在血液恶性肿瘤患者中经常发生突变，导致DNA甲基化谱异常和5hmC水平下降。TET2位于细胞核中，作为一种dna修饰酶，被认为是通过含TET2的蛋白复合物发挥其功能。确定TET2的相互作用网络可能是揭示TET2在细胞中发挥其功能的机制的关键。在这里，我们回顾了最近关于TET2相互作用的文献，并讨论了它们在TET2丢失介导的造血失调和血液恶性肿瘤发病机制中的可能作用。
Ten-eleven translocation family proteins are dioxygenases that oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in DNA, early steps of active DNA demethylation. TET2, the second member of TET protein family, is frequently mutated in patients with hematological malignancies, leading to aberrant DNA methylation profiling and decreased 5hmC levels. Located in the nucleus and acting as a DNA-modifying enzyme, TET2 is thought to exert its function via TET2-containing protein complexes. Identifying the interactome network of TET2 likely holds the key to uncover the mechanisms by which TET2 exerts its function in cells. Here, we review recent literature on TET2 interactors and discuss their possible roles in TET2 loss-mediated dysregulation of hematopoiesis and pathogenesis of hematological malignancies.