Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis
Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis
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DOI：
10.1007/s10815-021-02061-z
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发表时间：
2021-01-19
影响因子：
3.1
通讯作者：
Bentov, Yaakov
中科院分区：
文献类型：
--
作者：
Kenigsberg, Shlomit;Bentov, Yaakov
最近的出版物表明，与新鲜移植（IVF-IVF）相比，冻融胚胎移植（FET）的先兆子痫（PE）风险更高。这些研究是基于反映过时做法的旧数据。在本文中，我们想评估PE在当前辅助生殖技术（ART）practice.Methods的发病率，我们提出了在加拿大安大略省，2013年至2017年的FET，IVF-ET和自然受孕（NC）的所有出生的PE的发病率。我们还比较了我们的研究结果与以前的研究在荟萃分析，其中包括超过400万births.Results我们的研究结果表明，当代的ART实践的结果在相当的风险之间的PE FET和IVF-ET，但风险高于NC。这种RR可以通过使用用于FET的排卵子宫内膜制备物来进一步减弱。
Purpose Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice.Methods In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013-2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births.Results The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC.Conclusion Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.