Capsaicin: A novel radio‐sensitizing agent for prostate cancer
Capsaicin: A novel radio‐sensitizing agent for prostate cancer
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DOI：
10.1002/pros.22896
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发表时间：
2015-02
期刊：
影响因子：
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通讯作者：
N. Venier;A. Colquhoun;H. Sasaki;A. Kiss;L. Sugar;H. Adomat;N. Fleshner;L. Klotz;V. Venkateswaran-V.
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文献类型：
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作者：
N. Venier;A. Colquhoun;H. Sasaki;A. Kiss;L. Sugar;H. Adomat;N. Fleshner;L. Klotz;V. Venkateswaran-V.
放射增敏剂使肿瘤细胞对放射治疗(RT)的致命效应敏感，从而使用较低剂量的辐射实现同等的癌症控制，同时将对正常组织的不良影响降至最低。考虑到它们有限的毒性和很容易融入饮食的能力，饮食中天然存在的化合物是理想的潜在放射增敏剂。在这项研究中，我们研究了辣椒中的活性化合物辣椒素是否可以在前列腺癌(PCA)的临床前模型中调节对RT的反应。
Radio‐sensitizing agents sensitize tumor cells to the lethal effects of radiotherapy (RT) allowing for use of lower doses of radiation to achieve equivalent cancer control, while minimizing adverse effects to normal tissues. Given their limited toxicity and ability to easily integrate into the diet, compounds occurring naturally in the diet make ideal potential radio‐sensitizing agents. In this study, we have examined whether capsaicin, the active compound in chilli peppers, can modulate the response to RT in preclinical models of prostate cancer (PCa).