Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
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DOI：
10.1021/nn403126e
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发表时间：
2013-09-01
期刊：
影响因子：
17.1
通讯作者：
Dawson, Kenneth A.
中科院分区：
文献类型：
--
作者：
Kim, Jong Ah;Aberg, Christoffer;Dawson, Kenneth A.
纳米材料与生物系统的相互作用是目前快速发展的研究领域的焦点。虽然许多纳米颗粒与细胞相互作用而没有急性毒性反应，但氨基修饰的聚苯乙烯纳米颗粒已知会诱导细胞死亡。我们发现，通过降低剂量，细胞死亡在几天内保持在低水平，而有趣的是，细胞周期进程被阻止。在这种情况下，纳米颗粒的摄取，我们最近已经证明是受细胞周期进程的影响，随着时间的推移，由于缺乏细胞分裂的不同发展。这表明，相同的纳米颗粒可以根据暴露条件和累积的剂量触发不同的途径。
The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.