Role of macrophage tissue infiltration in metabolic diseases
Role of macrophage tissue infiltration in metabolic diseases
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DOI：
10.1097/01.mco.0000172571.41149.52
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发表时间：
2005-07-01
影响因子：
3.1
通讯作者：
Busse, R
中科院分区：
文献类型：
--
作者：
Bouloumié, A;Curat, CA;Busse, R
综述的目的白色脂肪组织是最佳能量平衡所必需的，脂肪量的过度发展与代谢综合征明显相关。事实上，脂肪细胞分泌一些特定的因子或'脂肪因子'，迫使重新评估的参与脂肪组织在广泛的生理和病理生理过程。肥胖最近被描述为一种“低度”炎症状态，这种状态被认为是肥胖相关病理发生的共同决定因素，即糖尿病和动脉粥样硬化。最近的研究结果最近的报告中的数量增加的巨噬细胞浸润的脂肪团在肥胖的个人导致的建议，脂肪组织本身是一个来源和网站的炎症。关于脂肪组织中巨噬细胞群体特征的最新数据。它们的起源、命运和激活将被考虑。将检查脂肪组织巨噬细胞在胰岛素抵抗和血管病变的发展中的潜在参与，以及在脂肪组织生长和代谢的控制中的潜在参与。
Purpose of review White adipose tissue is necessary for optimal energy homeostasis and the excessive development of fat mass is clearly associated with the metabolic syndrome. The fact that adipocytes secrete a number of specific factors or 'adipokines' has forced a reassessment of the involvement of adipose tissue in a wide range of physiological and pathophysiological processes. Obesity has recently been described as a 'low-grade' inflammatory condition, a state proposed to represent a common determinator in the genesis of obesity-associated pathologies, i.e. diabetes and atherosclerosis.Recent findings Recent reports of an increase in the number of macrophages that infiltrate the fat mass in obese individuals led to the suggestion that adipose tissue itself is a source and site of inflammation.Summary This review summarizes recent data on the characterization of the macrophage population in fat tissue. Their origin, fate and activation will be considered. The potential involvement of adipose tissue macrophages in the development of insulin resistance and vascular pathologies, as well as in the control of adipose tissue growth and metabolism, will be examined.