Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
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DOI：
10.1016/s0896-6273(00)80829-6
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发表时间：
1999-09-01
期刊：
影响因子：
16.2
通讯作者：
Cone, RD
中科院分区：
文献类型：
--
作者：
Cowley, MA;Pronchuk, N;Cone, RD
许多哺乳动物的能量储备相对稳定。维持能量稳态所必需的电路应该（1）感测脂肪组织中储存的能量的量，（2）感测并整合关于营养状态的多个相反信号，以及（3）提供调节能量摄入和消耗的输出以维持能量稳态。我们表明，下丘脑室旁核（PVH）内的单个神经元能够检测和整合食欲（神经肽Y [NPY]）和食欲（黑皮质素）信号，神经肽Y和黑皮质素是功能性拮抗剂的相互之间的PVH内的摄食行为的调节，和黑皮质素管理PVH内调节摄食行为和能量消耗。这些数据为PVH神经元内的adipostat提供了细胞基础，这些神经元似乎受到NPY和黑皮质素反应神经元的共同调节。
Energy stores are held relatively constant in many mammals. The circuitry necessary for maintaining energy homeostasis should (1) sense the amount of energy stored in adipose tissue, (2) sense and integrate the multiple opposing signals regarding nutritional state, and (3) provide output regulating energy intake and expenditure to maintain energy homeostasis. We demonstrate that individual neurons within the paraventricular nucleus of the hypothalamus (PVH) are capable of detection and integration of orexigenic (neuropeptide Y [NPY]) and anorexigenic (melanocortin) signals, that NPY and melanocortins are functional antagonists of each other within the PVH in the regulation of feeding behavior, and that melanocortin administration within the PVH regulates both feeding behavior and energy expenditure. These data provide a cellular basis for the adipostat within neurons in the PVH that appear to be jointly regulated by NPY- and melanocortin-responsive neurons.