Impact of age on survival of patients with pancreatic cancer after surgery: Analysis of SEER data
Impact of age on survival of patients with pancreatic cancer after surgery: Analysis of SEER data
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年龄对胰腺癌患者术后生存的影响：SEER 数据分析。
DOI：
10.1016/j.pan.2017.11.008
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发表时间：
2018-01-01
期刊：
影响因子：
3.6
通讯作者：
Wang, Chunyou
中科院分区：
文献类型：
--
作者：
Li, Xiaogang;Liu, Zhiqiang;Wang, Chunyou
背景资料：探讨年龄对接受手术的胰腺导管腺癌（PDAC）患者全因死亡和癌症特异性死亡的影响。材料和方法：回顾性研究了2004年至2013年期间接受手术的PDAC患者（N = 11，138），来自监测、流行病学和最终结果（SEER）癌症登记数据库。结果：多因素考克斯回归分析显示，全因死亡的危险性随年龄的增加而增加，年龄越大，全因死亡的危险性越大; 61-70岁组、71 - 80岁组和> 80岁组的风险比（95%置信区间，95%CI）分别为1.10（1.04-1.17）、1.31（1.23-1.38）、1.47（1.35 - 1.61），
Background: To explore the impact of age on all-cause death and cancer-specific death in patients with pancreatic duct adenocarcinoma (PDAC) undergoing surgery.Materials and methods: Individuals with PDAC undergoing surgery between 2004 and 2013 (N = 11,138) were retrospectively studied from the Surveillance, Epidemiology, and End Results (SEER) cancer registry database. The impact of age on all-cause death and cancer-specific death was assessed using Cox regression model and competing risk model respectively.Results: Multivariate Cox regression analysis indicated that the risks of all-cause death increased with age: hazard ratios (95% confidence interval, 95% CI) were 1.10 (1.04-1.17), 1.31 (1.23-1.38), 1.47 (1.35 -1.61) for groups 61-70 years, 71e80 years, and > 80 years, respectively, compared with