PLASMA ZINC AND COPPER CONCENTRATIONS IN RHEUMATOID-ARTHRITIS - INFLUENCE OF DIETARY FACTORS AND DISEASE-ACTIVITY
PLASMA ZINC AND COPPER CONCENTRATIONS IN RHEUMATOID-ARTHRITIS - INFLUENCE OF DIETARY FACTORS AND DISEASE-ACTIVITY
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DOI：
10.1093/ajcn/54.6.1082
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发表时间：
1991-12-01
影响因子：
7.1
通讯作者：
KONTTINEN, YT
中科院分区：
文献类型：
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作者：
HONKANEN, VEA;LAMBERG-ALLARDT, CH;KONTTINEN, YT
对 40 名类风湿性关节炎患者进行了彻底的 7 天饮食记录。通过逐步多元线性回归分析食物日记以及临床和实验室数据，以阐明饮食和炎症性疾病对血浆锌和铜浓度的影响。患者每日膳食中锌和铜的摄入量（24.3 +/- 7.54 和 3.48 +/- 1.55 mg/MJ）与普通芬兰饮食中的相应摄入量（24.0 和 3.68 mg/MJ）相当。在多变量分析中，血浆微量元素的最佳预测因素是疾病活动度的测量，而不是饮食因素。例外的是，在单变量（r = -0.638，P < 0.001）和多变量分析中，血浆铜-铜摄入量比与锌摄入量之间存在很强的相关性。这表明锌的摄入量在正常生理范围内会抑制铜的吸收。
Forty patients with rheumatoid arthritis performed a thorough 7-d diet recording. The food diaries were analyzed together with clinical and laboratory data by means of stepwise multiple linear regression to clarify the effects of both diet and the inflammatory disorder on the plasma concentrations of zinc and copper. The patients' daily dietary intakes of zinc and copper (24.3 +/- 7.54 and 3.48 +/- 1.55 mg/MJ) were comparable to the corresponding intakes in the ordinary Finnish diet (24.0 and 3.68 mg/MJ). In multivariate analyses the best predictors of plasma trace elements were the measures of disease activity and not the dietary factors. As an exception to this, there was a strong correlation between plasma copper-copper intake ratio and zinc intake both in univariate (r = -0.638, P < 0.001) and multivariate analysis. This suggests that zinc depresses copper absorption with intakes in normal, physiological ranges.