THE STATE OF FLUORIDES IN TOOTHPASTES
THE STATE OF FLUORIDES IN TOOTHPASTES
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DOI：
10.1016/0300-5712(89)90129-2
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发表时间：
1989-04-01
影响因子：
4.4
通讯作者：
HATTAB, FN
中科院分区：
文献类型：
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作者：
HATTAB, FN
配制有效的牙膏配方要求牙膏中的氟化物（F）必须以反应形式（生物活性）可用于牙釉质微环境。本研究的目的是评价牙膏配方中氟与研磨剂（清洁剂和抛光剂）的相容性，并监测老化对氟化钠/研磨剂混合物以及牙膏配方中氟可用性的影响。氟化钠/研磨剂混合物和牙膏配方中氟损失的速率和程度存在很大差异。将NaF溶液加入到含铝和含钙磨料中，在室温下储存1周后，所加入的F损失了60 - 90%。在1个月龄时，二水磷酸钙和硅酸铝吸附的F比碳酸钙多约4倍。另一方面，碳酸氢钠和偏磷酸钠在储存9个月后使20 - 25%的添加的F失活。二氧化硅在NaF和Na2PO3F（MFP）的结合和失活F方面是惰性的。含钙研磨剂与MFP的相容性明显高于NaF。牙膏储存12个月后，MFP-碳酸钙/硅酸钠牙膏中的可溶性F（初始F −加上水解PO3F2 −的F）是MFP-碳酸钙/硅酸铝牙膏的两倍。在30个月大的时候，NaF和胺F牙膏中的离子氟浓度和MFP牙膏中的可溶性氟浓度的顺序为MFP-二氧化硅（990份/106F）> NaF-碳酸氢钠（915份/106F）> MFP-dicalcium phosphate dihydrate（775份/106 F）> MFP-碳酸钙/硅酸钠（445份/106 F）>胺F-偏磷酸钠（245份/106 F）> MFP-碳酸钙/硅酸铝（120份/106 F）。6种牙膏中有2种在储存1年后，其总氟含量损失了一半以上。
Formulating an effective toothpaste formula requires that fluoride (F) in toothpaste must be made available to the enamel microenvironment in reactive form (bioactive). The aims of this study were to evaluate the compatibility of F with the abrasives (cleaning and polishing agents) used in toothpaste formulations and to monitor the effect of ageing on availability of F in NaF/abrasive mixtures as well as in toothpaste formulations.There was a great variation in the rate and extent of loss of F in the NaF/abrasive mixtures and in the toothpaste formulas. Addition of NaF solution to aluminium- and calcium-containing abrasives resulted in losses of 60–90 per cent of the added F after 1 week's storage at room temperature. At 1 month of age, calcium phosphate dihydrate and aluminium silicate adsorb about four times more F than calcium carbonate. On the other hand, sodium bicarbonate and sodium metaphosphate inactivated 20–25 per cent of the added F after 9 months' storage. Silica was inert in binding and inactivating F of NaF and Na2PO3F (MFP). Calcium-containing abrasives were markedly more compatible with MFP than with NaF.After 12 months of storing the toothpastes, the soluble F (initial F−plus F of hydrolysed PO3F2−) in MFP-calcium carbonate/sodium silicate toothpaste was twice as much as MFP-calcium carbonate/aluminium silicate toothpaste. At 30 months of age, the ionic F concentrations in NaF and amine F toothpastes and the soluble F concentrations in MFP toothpastes were in the order MFP-silica (990 parts/106F) > NaF-sodium bicarbonate (915 parts/106F) > MFP-dicalcium phosphate dihydrate (775 parts/106F) > MFP-calcium carbonate/sodium silicate (445 parts/106F) > amine F-sodium metaphosphate (245 parts/106F) > MFP-calcium carbonate/aluminium silicate (120 parts/106F). Two of the six tested toothpastes had lost more than half of their total F content after 1 year's storage.