Mechanism and functional significance of TRPC channel multimerization.
Mechanism and functional significance of TRPC channel multimerization.
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DOI：
10.1016/j.semcdb.2006.10.010
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发表时间：
2006-12
影响因子：
7.3
通讯作者：
M. Villereal
中科院分区：
文献类型：
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作者：
M. Villereal
Ca2+信号调节多种生物体内的许多重要生理事件。特别是，持续的Ca2+信号在控制细胞增殖、细胞分化和免疫细胞活化中起重要作用。产生持续Ca2+信号的两个关键因素是钙库操纵和受体操纵的Ca2+通道，它们在磷脂酶C（PLC）刺激下游被激活，响应于G蛋白偶联受体或生长因子受体刺激。这篇综述的一个目标是帮助澄清典型的瞬时受体电位（TRPC）蛋白在天然存储操作和天然受体操作通道的形成中的作用。为此，从内源性TRPC蛋白的研究数据将详细审查，以突出强有力的情况下，参与某些TRPC蛋白的一个亚型的存储操作的通道，它表现出低的Ca2+选择性的形成，在相反的CRAC亚型的存储操作的通道所表现出的高Ca2+选择性。本综述的第二个目标是强调越来越多的证据表明，本机存储操作和本机受体操作的通道形成的TRPC亚基的异源多聚化。此外，将提供证据来证明一些TRPC蛋白能够形成多种通道类型。
Ca2+signaling regulates many important physiological events within a diverse set of living organisms. In particular, sustained Ca2+signals play an important role in controlling cell proliferation, cell differentiation and the activation of immune cells. Two key elements for the generation of sustained Ca2+signals are store-operated and receptor-operated Ca2+channels that are activated downstream of phospholipase C (PLC) stimulation, in response to G-protein-coupled receptor or growth factor receptor stimulation. One goal of this review is to help clarify the role of canonical transient receptor potential (TRPC) proteins in the formation of native store-operated and native receptor-operated channels. Toward that end, data from studies of endogenous TRPC proteins will be reviewed in detail to highlight the strong case for the involvement of certain TRPC proteins in the formation of one subtype of store-operated channel, which exhibits a low Ca2+-selectivity, in contrast to the high Ca2+-selectivity exhibited by the CRAC subtype of store-operated channel. A second goal of this review is to highlight the growing body of evidence indicating that native store-operated and native receptor-operated channels are formed by the heteromultimerization of TRPC subunits. Furthermore, evidence will be provided to argue that some TRPC proteins are able to form multiple channel types.