Malignant glioma progression and nitric oxide
Malignant glioma progression and nitric oxide
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DOI：
10.1016/j.neuint.2006.07.001
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发表时间：
2006-12-01
影响因子：
4.2
通讯作者：
Castellani, Rudy J.
中科院分区：
文献类型：
--
作者：
Lam-Himlin, Dora;Espey, Michael G.;Castellani, Rudy J.
多形性胶质母细胞瘤是恶性胶质瘤中最常见的一种，尽管胶质瘤进展的分子途径有了最积极的治疗和最新的进展，但预后仍然很差。虽然在恶性胶质瘤的发病过程中，一氧化氮代谢受到的关注相对较少，但它可能与疾病过程密切相关。有趣的是，一氧化氮具有两种生理作用（例如，神经递质样活性，环GMP的刺激），和病理生理作用（例如，肿瘤转化，肿瘤新血管形成、诱导凋亡、自由基损伤）。此外，一氧化氮在特定的疾病状态下是神经保护性的还是神经毒性的，或者它是否增强或减弱恶性肿瘤的化疗效果，还没有得到解决。这篇评论讨论了多方面的活动，一氧化氮特别是恶性胶质瘤。(c)2006爱思唯尔有限公司保留所有权利。
Glioblastoma multiforme, the most common of the malignant gliomas, carries a dismal prognosis in spite of the most aggressive therapy and recent advances in molecular pathways of glioma progression. Although it has received relatively little attention in the setting of malignant gliomas, nitric oxide metabolism may be intimately associated with the disease process. Interestingly, nitric oxide has both physiological roles (e.g., neurotransmitter-like activity, stimulation of cyclic GMP), and pathophysiological roles (e.g., neoplastic transformation,. tumor neovascularization, induction of apoptosis, free radical damage). Moreover, whether nitric oxide is neuroprotective or neurotoxic in a given disease state, or whether it enhances or diminishes chemotherapeutic efficacy in malignant neoplasia, is unresolved. This review discusses the multifaceted activity of nitric oxide with particular reference to malignant gliomas. (c) 2006 Elsevier Ltd. All rights reserved.