Impairment of Cerebral Autoregulation Predicts Delayed Cerebral Ischemia After Subarachnoid Hemorrhage A Prospective Observational Study
Impairment of Cerebral Autoregulation Predicts Delayed Cerebral Ischemia After Subarachnoid Hemorrhage A Prospective Observational Study
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DOI：
10.1161/strokeaha.112.669788
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发表时间：
2012-12-01
期刊：
影响因子：
8.3
通讯作者：
Kirkpatrick, Peter J.
中科院分区：
文献类型：
--
作者：
Budohoski, Karol P.;Czosnyka, Marek;Kirkpatrick, Peter J.
背景和目的-迟发性脑缺血（DCI）是蛛网膜下腔出血（SAH）后不良结局的公认因素。最近的数据挑战了血管痉挛作为缺血的唯一原因的概念，并提出了一个多因素的过程，功能失调的脑自动调节作为一个组成部分。我们检验了这样一个假设，即使用基于近红外光谱的指数TOxa和基于经颅多普勒的指数Sxa检测到的早期自动调节失败可以预测DCI。
Background and Purpose-Delayed cerebral ischemia (DCI) is a recognized contributor to unfavorable outcome after subarachnoid hemorrhage (SAH). Recent data challenge the concept of vasospasm as the sole cause of ischemia and suggest a multifactorial process with dysfunctional cerebral autoregulation as a component. We tested the hypothesis that early autoregulatory failure, detected using near-infrared spectroscopy-based index, TOxa and transcranial Doppler-based index, Sxa, can predict DCI.Methods-In this prospective observational study we enrolled consecutive patients with aneurysmal SAH that occurred