Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex
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DOI：
10.1016/s0896-6273(01)00187-8
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发表时间：
2001-01-01
期刊：
影响因子：
16.2
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Philpot, BD;Sekhar, AK;Bear, MF
视觉皮层神经元的感受野受到感觉剥夺和经验的双向改变，但这些改变的突触基础尚不清楚。在这里，我们展示了对幼年大鼠视皮层第2/3层锥体细胞中突触NMDA受体(NMDAR)的组成和功能的双向、经验依赖的调节。视觉体验减少了NR2B受体的比例，缩短了NMDAR介导的突触电流的持续时间，并减少了高频刺激爆发时突触NMDAR电流的总和。视觉剥夺会产生相反的效果。尽管经验和剥夺的影响是可逆的，但突触修改的速度是不同的。经验可以在几个小时内引起突触传递的可察觉变化，而剥夺引起的变化需要几天时间。我们认为，NMDAR组成和功能的经验依赖性变化调节了视觉皮质接受野组织的发展。
The receptive fields of visual cortical neurons are bidirectionally modified by sensory deprivation and experience, but the synaptic basis for these changes is unknown. Here we demonstrate bidirectional, experience-dependent regulation of the composition and function of synaptic NMDA receptors (NMDARs) in visual cortex layer 2/3 pyramidal cells of young rats. Visual experience decreases the proportion of NR2B- only receptors, shortens the duration of NMDAR-mediated synaptic currents, and reduces summation of synaptic NMDAR currents during bursts of high-frequency stimulation. Visual deprivation exerts an opposite effect. Although the effects of experience and deprivation are reversible, the rates of synaptic modification vary. Experience can induce a detectable change in synaptic transmission within hours, while deprivation-induced changes take days. We suggest that experience-dependent changes in NMDAR composition and function regulate the development of receptive field organization in visual cortex.