A national burden of disease calculation: Dutch disability-adjusted life-years
A national burden of disease calculation: Dutch disability-adjusted life-years
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DOI：
10.2105/ajph.90.8.1241
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发表时间：
2000-08-01
影响因子：
12.7
通讯作者：
Hoeymans, N
中科院分区：
文献类型：
--
作者：
Melse, JM;Essink-Bot, ML;Hoeymans, N
目标.本研究使用国家流行病学数据和残疾权重，以残疾调整生命年（DALY）为单位估计了1994年荷兰48种主要原因造成的疾病负担，并探讨了相关问题和不确定性。方法。我们将来自荷兰人口动态统计、登记和调查的数据与荷兰残疾权重相结合，计算DALY中的疾病特定健康损失，DALY是按严重程度加权的寿命损失年数（YLLs）和残疾生存年数（YLLs）之和。YLD主要由心血管疾病和癌症造成，而YLD主要由精神障碍和一系列慢性躯体疾病（如慢性非特异性肺病和糖尿病）造成。这四个di-agnostic组造成了大约相同数量的Dyns。敏感性分析要求提高与失能权重相关的流行病学数据的准确性，特别是对于轻度和多发性疾病。伤残调整生命年方法在西欧国家一级似乎是可行的，并产生了可解释的结果，与成熟市场经济体全球疾病负担研究的结果相当。提出了改进方法及其适用性的建议。
Objectives. This study estimated the burden of disease due to 48 major causes in the Netherlands in 1994 in disability-adjusted life-years (DALY's), using national epidemiologic data and disability weights, and explored associated problems and uncertainties.Methods. We combined data from Dutch vital statistics, registrations, and surveys with Dutch disability weights to calculate disease-specific health loss in DALY's, which are the sum of years of life lost (YLLs) and years lived with disability (YLLs) weighted for severity.Results. YLLs were primarily lost by cardiovascular diseases and cancers, while YLDs were mostly lost by mental disorders and a range of chronic somatic disorders (such as chronic nonspecific lung disease and diabetes). These 4 di-agnostic groups caused approximately equal numbers of DALYs. Sensitivity analysis calls for improving the accuracy of the epidemiologic data in connection with disability weights, especially for mild and frequent diseases.Conclusions. The DALY approach appeared to be feasible at a national Western European level and produced interpretable results, comparable to results from the Global Burden of Disease Study for the Established Market Economies. Suggestions for improving the methodology and its applicability are presented.