Morphodynamics of ovarian follicles during oogenesis in mice
Morphodynamics of ovarian follicles during oogenesis in mice
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DOI：
10.1002/jemt.20302
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发表时间：
2006-06
影响因子：
2.5
通讯作者：
E. Sato;N. Kimura;M. Yokoo;Y. Miyake;J. Ikeda
中科院分区：
文献类型：
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作者：
E. Sato;N. Kimura;M. Yokoo;Y. Miyake;J. Ikeda
在小鼠中，卵原细胞进入第一次减数分裂的前期，并在胎儿卵巢中发育时分化为卵母细胞。出生后不久，所有卵母细胞都被阻滞在发育中的卵泡的前期晚期的盘状阶段；少数卵泡达到排卵期；其余的则因细胞凋亡而丢失。减数分裂的恢复和核进展到中期 II（卵母细胞成熟）发生在排卵卵泡中。在本文中，我们回顾了最近的形态学数据，这些数据阐明了细胞因子和糖胺聚糖（GAG）如何作为外源/内源因素参与小鼠卵泡发育、闭锁和卵子发生过程中的成熟。 (1) 微血管网络和血管生成因子（表皮生长因子；GAG）与选择性小鼠卵母细胞直径超过~20-30 μm 的生长密切相关。 (2)促性腺激素诱导的神经元凋亡抑制蛋白可能通过抑制卵泡发生过程中颗粒细胞凋亡而间接影响卵母细胞的存活。 (3)卵母细胞变性的方式取决于卵泡和卵母细胞的发育阶段，卵泡刺激素会加速卵母细胞的变性过程。 (4)小鼠卵母细胞/卵子的退化过程受到卵母细胞成熟过程中膨胀的卵丘中积累的肿瘤坏死因子-α的调节。 (5)在卵泡组织细胞间隙，特别是卵丘团中检测到胶体铁阳性物质。在卵母细胞减数分裂恢复期间，位于卵丘团和颗粒细胞层交织处的细胞变大。胶体铁阳性物质在增大的细胞的细胞间隙内广泛积累。显微镜。资源。技术，2006 年。© 2006 Wiley-Liss, Inc.
In the mouse, oogonia enter the prophase of the first meiotic division and differentiate into oocyte while developing in the fetal ovary. Shortly after birth, all oocytes are arrested in the dictyate stage of late prophase in the developing follicles; a small number of follicles reach the ovulatory stage; the rest are lost by apoptosis. The resumption of meiotic division and nuclear progression to metaphase II (oocyte maturation) occur in the ovulatory follicles. In this article we review recent morphological data that have clarified how cytokines and glycosaminoglycans (GAGs) are involved in mouse follicular development, atresia, and maturation during oogenesis, as exogenous/endogenous factors. (1) Microvascular networks and angiogenic factors (epidermal growth factor; GAGs) are deeply involved in selective mouse oocyte growth beyond ∼20–30 μm in diameter. (2) Gonadotropin‐inducible neuronal apoptosis inhibitory protein may indirectly affect oocyte survival as a result of the inhibition of apoptotic granulosa‐cell death during folliculogenesis. (3) The pattern of oocyte degeneration depends on follicle and oocyte developmental stages, and follicle stimulating hormone accelerates the process of degeneration of oocytes. (4) The process of degeneration of mouse oocytes/eggs is modulated by tumor necrosis factor‐α that is accumulated in the expanded cumulus during oocyte maturation. (5) A colloidal iron‐positive substance was detected in the intercellular spaces of follicular tissue, especially in the cumulus mass. Cells located where the cumulus mass and granulosa cell layer interwound became enlarged during the resumption of oocyte meiosis. Colloidal iron‐positive substances accumulated extensively within the intercellular spaces of the enlarged cells. Microsc. Res. Tech., 2006. © 2006 Wiley‐Liss, Inc.