National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012
复制标题
DOI：
10.1001/jamapediatrics.2016.2154
复制
发表时间：
2016-12-01
期刊：
影响因子：
26.1
通讯作者：
Camenga, Deepa R.
中科院分区：
文献类型：
--
作者：
Gaither, Julie R.;Leventhal, John M.;Camenga, Deepa R.
国家数据显示，阿片类药物处方做法的最新趋势与成人阿片类药物中毒住院之间存在平行关系。关于儿童和青少年阿片类药物中毒的住院情况，目前没有类似的估计数字。目的了解儿童和青少年阿片类药物中毒的发生率和住院特点。设计、环境和参与者回顾性分析从1997年1月1日至2012年12月31日每3年收集一次的美国儿科医院出院记录的全国代表性样本的连续横断面数据。使用儿童住院患者数据库确定1至19岁因阿片类药物中毒住院的13 052例出院记录。在收集时间框架内对数据进行分析。处方阿片类药物引起的中毒由《国际疾病分类，第九次修订，临床修改》中的代码确定。在15至19岁的青少年中，还查明了海洛因中毒。采用人口普查估计值计算每10万人的发病率。Cochran-Armitage趋势检验用于评估发病率随时间的变化。结果从1997年到2012年，共有13 052例（95% CI, 12 500-13 604）因处方阿片类药物中毒住院。每年每10万名1至19岁儿童因阿片类药物中毒住院的发生率从1.40 （95% CI, 1.24-1.56）上升到3.71 (95% CI, 3.44-3.98)，增加了165%（P为趋势）。
IMPORTANCE National data show a parallel relationship between recent trends in opioid prescribing practices and hospitalizations for opioid poisonings in adults. No similar estimates exist describing hospitalizations for opioid poisonings in children and adolescents.OBJECTIVE To describe the incidence and characteristics of hospitalizations attributed to opioid poisonings in children and adolescents.DESIGN, SETTING, AND PARTICIPANTS Retrospective analysis of serial cross-sectional data from a nationally representative sample of US pediatric hospital discharge records collected every 3 years from January 1, 1997, through December 31, 2012. The Kids' Inpatient Database was used to identify 13 052 discharge records for patients aged 1 to 19 years who were hospitalized for opioid poisonings. Data were analyzed within the collection time frame.MAIN OUTCOMES AND MEASURES Poisonings attributed to prescription opioidswere identified by codes from the International Classification of Diseases, Ninth Revision, Clinical Modification. In adolescents aged 15 to 19 years, poisonings attributed to heroin were also identified. Census estimates were used to calculate incidence per 100 000 population. The Cochran-Armitage test for trend was used to assess for changes in incidence over time.RESULTS From 1997 to 2012, a total of 13 052 (95% CI, 12 500-13 604) hospitalizations for prescription opioid poisonings were identified. The annual incidence of hospitalizations for opioid poisonings per 100 000 children aged 1 to 19 years rose from 1.40 (95% CI, 1.24-1.56) to 3.71 (95% CI, 3.44-3.98), an increase of 165%(P for trend,