Low-density lipoprotein subclass patterns and risk of myocardial infarction.
Low-density lipoprotein subclass patterns and risk of myocardial infarction.
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DOI：
10.1001/jama.1988.03410130125037
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发表时间：
1988-10
期刊：
影响因子：
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通讯作者：
M. Austin;J. Breslow;C. Hennekens;Julie E. Buring;W. Willett;R. Krauss
中科院分区：
文献类型：
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作者：
M. Austin;J. Breslow;C. Hennekens;Julie E. Buring;W. Willett;R. Krauss
在一项非致命性心肌梗死病例对照研究中，研究了低密度脂蛋白 (LDL) 亚类模式与冠心病的关联。通过梯度凝胶电泳对 109 名病例和 121 名对照者的血浆样本进行 LDL 亚类分析。以小而密的 LDL 颗粒占优势为特征的 LDL 亚类模式与心肌梗死风险增加三倍显着相关，与年龄、性别和相对体重无关。在具有这种 LDL 亚类模式的受试者中，血浆高密度脂蛋白胆固醇水平降低，甘油三酯、极低密度脂蛋白和中密度脂蛋白水平升高。多变量逻辑回归分析表明，高密度脂蛋白胆固醇和甘油三酯水平都会导致与小而密的 LDL 亚类模式相关的风险。因此，导致这种 LDL 亚类模式的代谢特征会导致一系列相互关联的脂蛋白变化，从而导致冠心病风险增加。
The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction. Subclasses of LDL were analyzed by gradient gel electrophoresis of plasma samples from 109 cases and 121 controls. The LDL subclass pattern characterized by a preponderance of small, dense LDL particles was significantly associated with a threefold increased risk of myocardial infarction, independent of age, sex, and relative weight. Plasma levels of high-density lipoprotein cholesterol were decreased, and levels of triglyceride, very low-density lipoproteins, and intermediate-density lipoproteins were increased in subjects with this LDL subclass pattern. Multivariate logistic regression analyses showed that both high-density lipoprotein cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern. Thus, the metabolic trait responsible for this LDL subclass pattern results in a set of interrelated lipoprotein changes that lead to increased risk of coronary heart disease.