Germline and conditional ghrelin knockout increases islet size.
Germline and conditional ghrelin knockout increases islet size.
复制标题
生殖系和条件性胃饥饿素基因敲除会增大胰岛的尺寸。
DOI：
10.1172/jci175799
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发表时间：
2023-12-15
影响因子：
15.9
通讯作者：
Holland, William L.
中科院分区：
文献类型：
--
作者：
Tatum, Sean M.;Holland, William L.
近年来的研究表明，基因或药理学增加或减少ghrelin对胰岛大小有增加或无影响。在本期JCI中，Gupta，Burstein及其同事采用了一种严格的方法来确定减少ghrelin对种系和条件ghrelin敲除小鼠以及不同年龄和体重的胰岛大小的影响。生殖系和条件性ghrelin基因敲除小鼠都与胰岛大小增加相关，这进一步加剧了老年和饮食诱导的肥胖。这些发现表明，调节生长激素释放肽可能会打开一个治疗窗口，以预防或治疗糖尿病。
Conflicting studies in recent years report that genetic or pharmacological increases or decreases in ghrelin either increase or have no effect on islet size. In this issue of the JCI, Gupta, Burstein, and colleagues applied a rigorous approach to determine the effects of reducing ghrelin on islet size in germline and conditional ghrelin-knockout mice as well as across varying ages and weight. Both germline and conditional ghrelin-knockout mice associated with increased islet size, which was further exacerbated by older age and diet-induced obesity. These findings suggest that modulation of ghrelin may open a therapeutic window to prevent or treat diabetes.
影响因子：
5.5
作者：
Pradhan G;Lee JH;Wu CS;Wang H;Lin L;Donti T;Graham BH;Rajan AS;Balasubramanyam A;Samson SL;Guo S;Sun Y
通讯作者：
Sun Y