THE ASSOCIATION OF ACUTE PHASE PROTEIN GENES WITH THE NUCLEAR MATRIX OF RAT-LIVER DURING EXPERIMENTAL INFLAMMATION
THE ASSOCIATION OF ACUTE PHASE PROTEIN GENES WITH THE NUCLEAR MATRIX OF RAT-LIVER DURING EXPERIMENTAL INFLAMMATION
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DOI：
10.1016/0006-291x(86)91125-3
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发表时间：
1986-06-13
影响因子：
3.1
通讯作者：
SCHREIBER, G
中科院分区：
文献类型：
--
作者：
BIRCH, HE;SCHREIBER, G
研究了急性时相蛋白基因与健康大鼠和患有炎症的大鼠肝脏中的核基质的关联。α 1-酸性糖蛋白和甲状腺素运载蛋白在正常肝脏中以低水平合成，并且没有观察到它们的基因的基质关联。白蛋白、转铁蛋白和β-正常肝脏中纤维蛋白原链的合成水平要高得多，并且发现它们的基因与核基质相关。炎症诱导的α 1-酸性糖蛋白和β 1-酸性糖蛋白合成的增加纤维蛋白原链导致其基因的更强的基质缔合。然而，炎症诱导的白蛋白合成减少并不影响其基因的基质结合。
The association of acute phase protein genes with the nuclear matrix in livers from healthy rats and rats suffering from inflammation was studied. .alpha.1-Acid glycoprotein and transthyretin are synthesized at low levels in normal liver and no matrix association of their genes was observed. Albumin, transferrin and the .beta.-chain of fibrinogen are synthesized at much higher levels in normal liver and their genes were found to be associated with the nuclear matrix. An inflammation induced increase in synthesis of .alpha.1-acid glycoprotein and the .beta.-chain of fibrinogen resulted in stronger matrix association of their genes. However, inflammation induced decrease in the synthesis of albumin did not influence matrix association of its gene.