Myometrial inflammation in human delivery and its association with labor and infection
Myometrial inflammation in human delivery and its association with labor and infection
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DOI：
10.1309/kc6kdtx98lfyb3j7
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发表时间：
2003-08-01
影响因子：
3.5
通讯作者：
Heinonen, ST
中科院分区：
文献类型：
--
作者：
Keski-Nisula, LT;Aalto, ML;Heinonen, ST
对 648 名在不同妊娠期接受剖宫产的连续妇女评估了组织病理学检查确定的蜕膜和子宫肌层样本中是否存在炎症，以及子宫肌层炎症与不同孕产妇感染发病率和分娩相关临床变量之间的关联。总共研究了 1,205 个组织学样本（559 个蜕膜样本和 646 个子宫肌层样本）。在正常妊娠中，分娩前很少检测到子宫肌层炎症病变，表明这些病例存在异常。在伴有晚期宫颈扩张的胎膜破裂后以及患有临床绒毛膜羊膜炎的患者中，子宫肌层样本中通常有白细胞浸润，唇部呈中等和明显的密度。在高危足月产妇中，中度至显着的子宫肌层炎症对于预测术后子宫内膜炎没有诊断价值。我们的研究首次显示了未经选择的连续孕妇的子宫肌层炎症频率，因此，对于更好地了解人类分娩期间子宫肌层炎症反应非常重要。
The presence of inflammation in decidual and myometrial samples as defined by histopathologic examination and the association between the myometrial inflammation and different maternal infectious morbidity and labor related clinical variables were evaluated in 648 consecutive women who underwent cesarean section at various gestational periods. Altogether, 1,205 histologic (559 decidual and 646 myometrial) samples were studied.In normal pregnancies, myometrial inflammatory lesions were detected rarely before parturition, indicating their abnormality in these cases. After rupture fetal membranes with advanced cervical dilatation and in patients with clinical chorioamnionitis, in myometrial samples commonly were infiltrated by leukocytes, lip to moderate and marked densities. Moderate to marked myometrial inflammation showed no diagnostic value in high-risk term parturients for the prediction of postoperative endometritis. Our study is the first to show the frequency of myometrial inflammation in nonselected consecutive pregnant women and, thus, is important for better understanding the myometrial inflammatory, response during human parturition.