Oxytocin modulates the temporal dynamics of resting EEG networks
Oxytocin modulates the temporal dynamics of resting EEG networks
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DOI：
10.1038/s41598-019-49636-6
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发表时间：
2019-09
影响因子：
4.6
通讯作者：
Bastian Schiller;T. Koenig;M. Heinrichs
中科院分区：
文献类型：
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作者：
Bastian Schiller;T. Koenig;M. Heinrichs
催产素是社会互动的关键调节器，但我们对其对神经心理过程的潜在影响知之甚少。我们使用时空脑电微态分析来揭示催产素对神经网络中内在产生的活动的时间动力学的影响。鉴于催产素已知的抗焦虑作用，我们假设它增加了四个原型脑电休息网络的时间稳定性。在我们记录他们的静息脑电之前，86名男性参与者接受了催产素或安慰剂的鼻腔注射。正如假设的那样，催产素在全球范围内增加了四个原型休息网络的平均持续时间，特别是减少了与自主加工相关的网络的出现和覆盖，从而有利于更多地覆盖与注意相关的网络。此外，这些神经生理学变化在焦虑程度高且主观感受到催产素治疗效果较强的参与者中更为明显。总而言之，我们的研究表明，催产素通过增加神经休息网络的时间稳定性来减少神经休息网络之间的快速切换。具体地说，它似乎减少了大脑准备内部导向的自主信息处理的需要，从而使社会信息的外部导向处理成为可能。静息网络时间动态的变化可能是催产素抗焦虑作用的基础，这可能会为创新的心理生物治疗策略提供信息。
Oxytocin is a key modulator of social interaction, but we possess little knowledge of its underlying effects on neuropsychological processes. We used a spatio-temporal EEG microstates analysis to reveal oxytocin’s effects on the temporal dynamics of intrinsically generated activity in neural networks. Given oxytocin’s known anxiolytic effects, we hypothesized that it increases the temporal stability of the four archetypal EEG resting networks. Eighty-six male participants had received oxytocin or placebo intranasally before we recorded their resting EEG. As hypothesized, oxytocin globally increased the average duration of the four archetypal resting networks and specifically decreased the occurrence and coverage of an autonomic processing-related network to benefit greater coverage of an attention-related network. Moreover, these neurophysiological changes were more pronounced in participants with high anxiety levels and strong subjectively experienced effects of the oxytocin administration. In sum, our study shows that oxytocin reduces rapid switching among neural resting networks by increasing their temporal stability. Specifically, it seems to reduce the brain’s need for preparing the internally-oriented processing of autonomic information, thus enabling the externally-oriented processing of social information. Changes in the temporal dynamics of resting networks might underlie oxytocin’s anxiolytic effects - potentially informing innovative psychobiological treatment strategies.