Severe Pain Profiles and Associated Sociodemographic and Clinical Characteristics in Individuals With Sickle Cell Disease.
Severe Pain Profiles and Associated Sociodemographic and Clinical Characteristics in Individuals With Sickle Cell Disease.
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DOI：
10.1097/ajp.0000000000000957
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发表时间：
2021-09-01
期刊：
影响因子：
--
通讯作者：
Shah NR
中科院分区：
文献类型：
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作者：
Knisely MR;Tanabe PJ;Yang Q;Masese R;Jiang M;Shah NR
确定具有不同严重疼痛特征的镰状细胞病（SCD）患者的类别，并评估类别之间人口统计学、临床和心理社会特征的差异。这项探索性的横断面研究使用了杜克大学SCD实施联盟研究登记处收集的数据。使用成人镰状细胞生活质量测量系统疼痛项目数据从291名成人SCD，潜在类分析被用来确定类的个人共享不同的严重疼痛配置文件。双变量分析和逻辑回归模型被用来评估疼痛类型与人口统计学、临床和社会心理特征之间的关系。确定了三个具有不同重度疼痛特征的类别：低频和影响类别（n=73）、中频和影响类别（n=94）和高频和影响类别（n=124）。与低频率和影响类别相比并控制年龄和性别时，中频率和影响类别的患者更有可能：（p= 0.031）失业者（p=.013）;报告睡眠更差（p= 0.005）和社会功能（p= 0.005）;有较少的情绪困扰（p= 0.004）;将疼痛描述为“疼痛”（p= 0.002）;并且有先前的SCD相关肺部并发症（p= 0.016）。与低频率和影响类别相比，高频率和影响类别中的个体：社会功能更差（p<.001）和先前的SCD相关肺部并发症（p=.006）;将疼痛描述为“疼痛”（p<.001）;并且每天服用SCD止痛药（p=.001）。SCD中的重度疼痛经历是复杂的;然而，有一些亚组的人报告了类似的重度疼痛经历。
To identify classes of individuals with sickle cell disease (SCD) who share distinct severe pain profiles and evaluate differences in demographic, clinical, and psychosocial characteristics between classes. This exploratory, cross-sectional study used data collected for the SCD Implementation Consortium Research Registry at Duke University. Using Adult Sickle Cell Quality of Life-Measurement System pain-item data from 291 adults with SCD, latent class analysis was used to determine classes of individuals sharing distinct severe pain profiles. Bivariate analyses and logistic regression models were used to assess the relationships between pain profile classes and demographic, clinical, and psychosocial characteristics. Three classes sharing distinct severe pain profiles were identified: Low Frequency and Impact class (n=73), Moderate Frequency and Impact class (n=94), and High Frequency and Impact class (n=124). When compared to the Low Frequency and Impact class and controlling for age and sex, patients in the Moderate Frequency and Impact class were more likely to: be female (p=.031) and unemployed (p=.013); report worse sleep (p=.005) and social functioning (p=.005); have less emotional distress (p=.004); describe pain as “sore” (p=.002); and have previous SCD-related lung complications (p=.016). When compared to the Low Frequency and Impact class, individuals in the High Frequency and Impact class: had worse social functioning (p<.001) and previous SCD-related lung complications (p=.006); described pain as “sore” (p<.001); and were taking pain medication daily for SCD (p=.001). Severe pain experiences in SCD are complex; however, there are subgroups of people who report similar experiences of severe pain.