Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
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DOI：
10.3174/ajnr.a6856
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发表时间：
2021-01-01
影响因子：
3.5
通讯作者：
van de Ven, K. C. C.
中科院分区：
文献类型：
--
作者：
Baas, K. P. A.;Petr, J.;van de Ven, K. C. C.
背景和目的：尽管动脉自旋标记在各种脑部病理中显示出附加的诊断价值，但其在临床实践中的应用有限。为了鼓励临床采用ASL，我们调查了CBF测量的再现性和采集参数变化的影响相比，建议ASL implementation.MATERIALS和METHODS：34名志愿者（平均年龄，57.8 +/- 17.0岁;范围，22-80岁）进行了两个单独的会议（1.5T和3 T扫描仪从一个单一的供应商）使用15通道头部线圈。两个会话均包含使用供应商推荐的采集参数（基于推荐纸张）进行的重复3D和2D伪连续动脉自旋标记扫描，随后进行3次3D伪连续动脉自旋标记扫描，2次标记后延迟为1600和2000 ms，1次空间分辨率增加。所有扫描均为单次标记后延迟。intransession（相同的收购，扫描间隔五分钟）和intersession（第一个2D和3D收购的两个会话）的再现性进行了检查，以及对CBF.Results的参数变化的影响：Intransession CBF再现性是类似的跨图像读出和场强（受试者内的变异系数在4.0%和6.7%之间）。受试者间的变异系数范围为6.6%至14.8%。在3 T下，具有较高空间分辨率的3D采集导致GM和WM信号的混合较少，从而降低了2D和3D采集之间GM CBF的偏倚（Delta CBF = 2.49 mL/100 g/min [P < .001]）。标记后延迟变化引起适度偏倚（δ CBF在-3.78 [P < .001]和2.83 [P < .001] mL/100 g/min之间）。结论：动脉自旋标记成像在两种场强下均可重现，重现性与年龄无显著相关性。此外，3 T允许更多的采集参数变化，并允许更广泛的优化，以便可以比较3D和2D采集。
BACKGROUND AND PURPOSE:Although the added diagnostic value of arterial spin-labeling is shown in various cerebral pathologies, its use in clinical practice is limited. To encourage clinical adoption of ASL, we investigated the reproducibility of CBF measurements and the effects of variations in acquisition parameters compared to the recommended ASL implementation.MATERIALS AND METHODS:Thirty-four volunteers (mean age, 57.8 +/- 17.0 years; range, 22-80 years) underwent two separate sessions (1.5T and 3T scanners from a single vendor) using a 15-channel head coil. Both sessions contained repeated 3D and 2D pseudocontinuous arterial spin-labeling scans using vendor-recommended acquisition parameters (recommendation paper-based), followed by three 3D pseudocontinuous arterial spin-labeling scans, two with postlabeling delays of 1600 and 2000 ms and one with increased spatial resolution. All scans were single postlabeling delay. Intrasession (identical acquisitions, scanned five minutes apart) and intersession (first 2D and 3D acquisitions of two sessions) reproducibility was examined as well as the effect of parameter variations on CBF.RESULTS:Intrasession CBF reproducibility was similar across image readouts and field strengths (within-subject coefficient of variation between 4.0% and 6.7%). Intersession within-subject coefficient of variation ranged from 6.6% to 14.8%. At 3T, the 3D acquisition with a higher spatial resolution resulted in less mixing of GM and WM signal, thus decreasing the bias in GM CBF between the 2D and 3D acquisitions (Delta CBF = 2.49 mL/100g/min [P < .001]). Postlabeling delay variations caused a modest bias (Delta CBF between -3.78 [P < .001] and 2.83 [P < .001] mL/100g/min).CONCLUSIONS:Arterial spin-labeling imaging is reproducible at both field strengths, and the reproducibility is not significantly correlated with age. Furthermore, 3T tolerates more acquisition parameter variations and allows more extensive optimizations so that 3D and 2D acquisitions can be compared.