Relation of anthropometry to malaria morbidity and immunity in Papua New Guinean children
Relation of anthropometry to malaria morbidity and immunity in Papua New Guinean children
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DOI：
10.1093/ajcn/68.3.734
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发表时间：
1998-09-01
影响因子：
7.1
通讯作者：
Alpers, MP
中科院分区：
文献类型：
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作者：
Genton, B;Al-Yaman, F;Alpers, MP
营养不良和疟疾之间的相互作用是复杂的，有证据表明营养不良会降低对疟疾的易感性。为了调查人体测量值与随后的疟疾发病率之间的关系，并检查观察到的影响是否由于与宿主免疫的相互作用，我们在巴布亚新几内亚东塞匹克省沃塞拉对136名10至小于120个月的儿童进行了1年的随访。在基线时，21%发育不良，10%被浪费，5%既发育不良又被浪费。在调整了年龄和使用蚊帐的因素后，基线时的身高年龄比z评分（HAZ）预测了第二年恶性疟疾临床发作的次数：发病率随着HAZ的增加而增加。对特定疟疾抗原的体液反应在消瘦儿童中最低。在营养良好和营养不良的儿童中，淋巴细胞增生性反应的发生率无显著差异。相反，营养不良儿童的细胞因子产生率高于营养良好儿童。我们的研究结果支持了发育迟缓而不是消瘦可以预防恶性疟疾的观点。其机制可能与营养不良儿童在特定疟疾抗原刺激下产生某些细胞因子的能力提高有关。
The interaction between malnutrition and malaria is complex and there is evidence that malnutrition decreases the susceptibility to malaria. To investigate the relation between anthropometric measurements and subsequent malaria morbidity and to examine whether the effect observed was due to interaction with host immunity, we followed for 1 y a cohort of 136 children aged 10 to < 120 mo in Wosera, East Sepik Province, Papua New Guinea. At baseline, 21% were stunted, 10% were wasted, and 5% were both stunted and wasted. After adjustment for age and use of bed nets, height-for-age z score (HAZ) at baseline predicted the number of clinical episodes of falciparum malaria during the following year: incidence rate increased with increasing HAZ. Humoral responses to specific malarial antigens were lowest in the wasted children. The prevalence of lymphoproliferative responders was not significantly different between well-nourished and undernourished children. In contrast, the prevalence of cytokine producers was higher in the undernourished than in the well-nourished children. Our findings support the view that stunting but not wasting protects against falciparum malaria. The mechanism may be related to an improved ability of malnourished children to produce certain cytokines in response to stimulation by specific malarial antigens.