Occupational pesticide exposure and semen quality among Chinese workers
Occupational pesticide exposure and semen quality among Chinese workers
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DOI：
10.1097/00043764-200010000-00004
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发表时间：
2000-10-01
影响因子：
3.2
通讯作者：
Xu, XP
中科院分区：
文献类型：
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作者：
Padungtod, C;Savitz, DA;Xu, XP
本研究调查了中国工人职业农药暴露与精液质量之间的关系。从附近两家工厂招募了 32 名接触过有机磷农药的男性工人和 43 名未接触过有机磷农药的男性工人并进行了访谈。轮班后，收集精液和尿液样本进行农药代谢物分析。分析精液样本的精子浓度、活力百分比和正常结构百分比。在暴露组内，高暴露亚组和低暴露亚组的平均班末尿液对硝基苯酚水平分别为 0.22 和 0.15 mg/L。个体精液参数的线性回归分析显示，精子浓度显着降低（35.9 x 10(6) vs 62.8 X 10(6)，p < 0.01）和活力百分比（47% vs 57%，p = 0.03），但结构正常的精子百分比没有显着降低（57% vs 61%，p = 0.13）。多变量模型显示平均精液参数出现显着的整体变化。职业接触乙基对硫磷和甲胺磷似乎对精液质量有中等程度的不利影响。
This study investigated the association between occupational pesticide exposure and semen quality among Chinese workers. Male workers, 32 who were exposed to organophosphate pesticides and 43 who were not exposed were recruited from two nearby factories and interviewed. Following a work shift, semen and urine samples were collected for pesticide metabolite analysis. Semen samples were analyzed for sperm concentration, percentage of motility, and percentage of normal structure. Within the exposed group, the mean end-of-shift urinary p-nitrophenol levels were 0.22 and 0.15 mg/L for the high- and low-exposure subgroups, respectively. Linear regression analysis of individual semen parameters revealed a significant reduction of sperm concentration 35.9 x 10(6) vs 62.8 X 10(6), p < 0.01) and percentage of motility (47% vs 57%, p = 0.03) but not percentage of sperm with normal structure (57% vs 61%, p = 0.13). Multivariate modeling showed a significant overall shift in the mean semen parameter. Occupational exposure to ethylparathion and methamidophos seems to have a moderately adverse effect on semen quality.