[2 + 2] photocycloadditions in the synthesis of chiral molecules.
[2 + 2] photocycloadditions in the synthesis of chiral molecules.
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[2 2] 手性分子合成中的光环加成。
DOI：
10.1126/science.4038558
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Schreiber,SL
中科院分区：
文献类型：
--
作者：
Schreiber,SL
光化学介导的[2 + 2]环加成反应是合成手性分子的一种重要方法。这些反应可以在多克规模上进行，并且通常以高产率和立体控制进行。这些功能，在随后的化学转化中的四元环光产物的有用性能相结合，使它们在合成设计的早期阶段有吸引力的选择。不饱和官能团的各种组合可以参与该反应过程。因此，这些化学反应可以是与各种靶分子的合成有关的问题的经济解决方案。
A strategy for the synthesis of chiral molecules that receives growing popularity among organic chemists employs the photochemically mediated [2 + 2] cycloaddition reaction. These reactions can be performed on a multigram scale and often proceed with high yield and with stereocontrol. These features, in combination with the useful properties of the four-membered ring photoproducts in subsequent chemical transformations, make them attractive options in the early stage of a synthesis design. Various combinations of unsaturated functional groups can participate in this reaction process. Accordingly, these chemical reactions can be economical solutions to problems relating to the synthesis of a variety of target molecules.