Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma
Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma
复制标题
富含 Jumonji AT 的相互作用结构域 1B 和 PHD 指蛋白 2 的过度表达参与食管鳞状细胞癌的进展。
DOI：
10.1016/j.acthis.2012.04.001
复制
发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Xu, Li-Yan
中科院分区：
文献类型：
--
作者：
Sun, Ling-Ling;Sun, Xing-Xing;Xu, Li-Yan
Jumonji AT富含相互作用域1B(JARID1B)和PhD Finger Protein 2(PHF2)是组蛋白去甲基酶的成员，已被发现与多种类型的肿瘤有关。然而，JARID1B和PHF2在食管鳞癌中的表达及其预后意义仍不清楚。本研究采用免疫组织化学方法检测了120例食管鳞癌组织芯片中JARID1B和PHF2的表达。我们的结果表明，JARID1B和PHF2在食管癌中高表达。此外，JARID1B核表达水平与组织学分级显著相关(P=0.003)。Kaplan-Meier生存分析显示，JARID1B和PHF2胞浆高表达与ESCC患者总生存率降低有关，而JARID1B胞核高表达与总生存率高相关，但无统计学意义。总体而言，我们的数据表明JARID1B和PHF2在ESCC中高表达，它们可能在ESCC的启动和/或进展过程中发挥关键作用。(C)2012年爱思唯尔股份有限公司。版权所有。
Jumonji AT-rich interactive domain 1B (JARID1B) and PHD finger protein 2 (PHF2), members of the histone demethylases, have been found to be involved in many types of tumors. However, the expression and prognostic significance of JARID1B and PHF2 in esophageal squamous cell carcinoma (ESCC) still remains unclear. In this study, JARID1B and PHF2 expression were detected on tissue microarrays of ESCC samples in 120 cases using immunohistochemical staining. Our results showed that JARID1B and PHF2 were overexpressed in ESCCs. In addition, a significant correlation was observed between JARID1B nuclear expression level and histological grade (P=0.003). Kaplan-Meier survival analysis showed a tendency that high cytoplasmic expression of JARID1B and PHF2 was associated with decreased overall survival of ESCC patients, whereas JARID1B high expression in the nucleus was associated with high overall survival, although there was no statistical significance. Overall, our data suggest that JARID1B and PHF2 are overexpressed in ESCC and that they may play crucial roles in the course of ESCC initiation and/or progression. (C) 2012 Elsevier GmbH. All rights reserved.