Morphological and immunocytochemical characteristics of PC12 cell grafts in rat brain.
Morphological and immunocytochemical characteristics of PC12 cell grafts in rat brain.
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大鼠脑中 PC12 细胞移植物的形态学和免疫细胞化学特征。
DOI：
10.1111/j.1749-6632.1987.tb23684.x
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发表时间：
1987
影响因子：
5.2
通讯作者：
Jaeger,CB
中科院分区：
文献类型：
--
作者：
Jaeger,CB
最近的几项研究表明，胚胎神经移植对脑损伤或内分泌缺陷动物的功能恢复有有益的影响。从这项工作中可以明显看出，这种移植物可以作为生物合成的假体，提供一种重要的递质或激素。其他物质，如营养物质，可以帮助受损途径的再生，也可以通过这种移植物释放。然而，典型的神经移植物除了特定的神经元外，还由非神经元细胞类型组成，这使得很难确定各种因素的来源或目标。因此，本研究选择仅由一种细胞类型组成的同质移植物，以确定潜在的营养效应，并进一步阐明神经移植物和宿主脑之间细胞相互作用的方向和性质。
Several recent studies have suggested a beneficial influence of embryonic neural grafts on the recovery of function of animals with brain lesions or endocrine deficiencies.’s6It is apparent from this work that such grafts can serve as biosynthetic prostheses to supply a vital transmitter or hormone. Other materials, such as trophic substances, which could aid the regeneration of the injured pathways, may also be released by such grafts.’Typical neural transplants, however, are composed of nonneuronal cell types, in addition to specific neurons,’,’making it difficult to pinpoint the source or target of various factors. Thus, homogeneous transplants consisting of only one cell type were chosen for this study so as to identify potential trophic effects and further clarify the direction and nature of cell interactions between neural transplants and the host brain.