The role of cancer stem cells in relapse of solid tumors.
The role of cancer stem cells in relapse of solid tumors.
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DOI：
10.2741/478
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Yang Yu;Grace Ramena;R. Elble
中科院分区：
文献类型：
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作者：
Yang Yu;Grace Ramena;R. Elble
继发部位的复发，通常在原发肿瘤切除后数年，是实体瘤相关死亡率的主要原因。转移、对化疗和放疗的抵抗以及最终的复发归因于称为癌症干细胞（CSC）的独特肿瘤亚群。在这篇综述中，我们考虑了导致这些结果的CSC的特性，特别是上皮-间充质转化、干细胞和肿瘤发生之间的关系。我们比较了乳腺癌，胶质母细胞瘤和黑色素瘤的最新临床和实验室研究，这些研究说明了目前大多数抗癌方案如何选择具有间充质和CSC特性的细胞，从而播下复发的种子。最后，我们讨论了新兴的联合治疗的范例，目标CSC和非CSC肿瘤成分。
Recurrence at secondary locations, often years after removal of the primary tumor, accounts for most of the mortality associated with solid tumors. Metastasis, resistance to chemo- and radiotherapy, and eventual relapse have been attributed to a distinct tumor subpopulation known as cancer stem cells (CSCs). In this review, we consider the properties of CSCs that lead to these outcomes, in particular the relation between epithelial-to-mesenchymal transition, stemness, and tumor initiation. We compare recent clinical and laboratory studies of breast cancer, glioblastoma, and melanoma that illustrate how most current anticancer regimens select for cells with mesenchymal and CSC properties and therefore sow the seeds of relapse. Finally, we discuss the emerging paradigm of combined therapy that targets both CSC and non-CSC tumor components.