Mortality (1950-1999) and cancer incidence (1969-1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses.
Mortality (1950-1999) and cancer incidence (1969-1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses.
复制标题
霍普港队列研究中暴露于镭、铀和γ射线剂量的独特组合的工人的死亡率（1950-1999）和癌症发病率（1969-1999）。
DOI：
10.1136/bmjopen-2012-002159
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Frost,StanleyE
中科院分区：
文献类型：
--
作者：
Zablotska,LydiaB;Lane,RachelSD;Frost,StanleyE
铀加工工人暴露于矿尘中的铀和镭化合物以及γ射线辐射，但较少暴露于铀矿工人特有的氡衰变产物（RDP）。我们研究了这些暴露的风险，在一个队列的工人从霍普港镭和铀精炼厂和加工厂。设计一个回顾性队列研究与仔细记录的暴露，这允许分离的人与主要暴露于镭和铀。设置霍普港，安大略，加拿大，没有采矿经验的铀加工厂。（1932-1980），并追踪死亡率（1950-1999）和癌症发病率（1969-1999）。Poisson回归被用来评估累积RDP暴露和γ-射线剂量和死亡原因和癌症可能与镭和铀processing.ResultsOverall，工人的死亡率和癌症发病率较低，与一般加拿大人口之间的关联。在仅限于男性（n=2645）的分析中，人-年加权平均累积RDP暴露量为15.9工作水平月（WLM），平均累积全身γ射线剂量为134.4毫西弗。 我们观察到，由于接触RDP，死亡率和肺癌发病率的辐射风险略有增加，但无统计学意义（超额相对风险/100 WLM分别为0.21，95%CI <-0.45至1.59和0.77，95%CI <-0.19至3.39），接触镭和铀的风险相似。所有其他原因的死亡和癌症发病率没有显着相关的RDP暴露或γ-射线剂量或两者的组合。ConclusionsIn一个最大的队列研究的工人暴露于镭，铀和γ-射线剂量，没有显着的辐射相关的风险，观察到任何癌症部位或死因。对接触镭和铀加工副产品的其他工人群体进行持续跟踪和汇总，可以提供宝贵的见解，以了解职业风险和铀矿工人的疑似风险差异。
ObjectivesUranium processing workers are exposed to uranium and radium compounds from the ore dust and to γ-ray radiation, but less to radon decay products (RDP), typical of the uranium miners. We examined the risks of these exposures in a cohort of workers from Port Hope radium and uranium refinery and processing plant.DesignA retrospective cohort study with carefully documented exposures, which allowed separation of those with primary exposures to radium and uranium.SettingsPort Hope, Ontario, Canada, uranium processors with no mining experience.Participants3000 male and female workers first employed (1932–1980) and followed for mortality (1950–1999) and cancer incidence (1969–1999).Outcome measuresCohort mortality and incidence were compared with the general Canadian population. Poisson regression was used to evaluate the association between cumulative RDP exposures and γ-ray doses and causes of death and cancers potentially related to radium and uranium processing.ResultsOverall, workers had lower mortality and cancer incidence compared with the general Canadian population. In analyses restricted to men (n=2645), the person-year weighted mean cumulative RDP exposure was 15.9 working level months (WLM) and the mean cumulative whole-body γ-ray dose was 134.4 millisieverts. We observed small, non-statistically significant increases in radiation risks of mortality and incidence of lung cancer due to RDP exposures (excess relative risks/100 WLM=0.21, 95% CI <−0.45 to 1.59 and 0.77, 95% CI <−0.19 to 3.39, respectively), with similar risks for those exposed to radium and uranium. All other causes of death and cancer incidence were not significantly associated with RDP exposures or γ-ray doses or a combination of both.ConclusionsIn one of the largest cohort studies of workers exposed to radium, uranium and γ-ray doses, no significant radiation-associated risks were observed for any cancer site or cause of death. Continued follow-up and pooling with other cohorts of workers exposed to by-products of radium and uranium processing could provide valuable insight into occupational risks and suspected differences in risk with uranium miners.