2 TYROSINASE NONAPEPTIDES RECOGNIZED ON HLA-A2 MELANOMAS BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES
2 TYROSINASE NONAPEPTIDES RECOGNIZED ON HLA-A2 MELANOMAS BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES
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DOI：
10.1002/eji.1830240340
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发表时间：
1994-03-01
影响因子：
5.4
通讯作者：
BOON, T
中科院分区：
文献类型：
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作者：
WOLFEL, T;VANPEL, A;BOON, T
来自几个黑色素瘤患者的大量细胞溶解T淋巴细胞(CTL)克隆被发现识别大多数来自人类白细胞抗原A2患者的黑色素瘤。我们以前已经报道过两个这样的CTL克隆识别由人类白细胞抗原A2呈现的酪氨酸酶基因的产物。在这里，我们展示了这些CTL克隆中的一个识别由酪氨酸酶假定信号序列的前九个氨基酸编码的肽。另一个CTL克隆识别与368-376个氨基酸相对应的不同酪氨酸酶肽。这两种多肽都含有人类白细胞抗原-A2结合多肽的共同基序。
A number of cytolytic T lymphocyte (CTL) clones derived from several melanoma patients have been found to recognize a majority of melanomas from HLA-A2 patients. We have reported previously that two such CTL clones recognize a product of the tyrosinase gene that is presented by HLA-A2. Here we show that one of these CTL clones recognizes a peptide encoded by the first nine amino acids of the putative signal sequence of tyrosinase. The other CTL clone recognizes a different tyrosinase peptide corresponding to amino acids 368-376. Both peptides contain consensus motifs of HLA-A2 binding peptides.